Naslov
Novel cyano- and amidino-substituted styrylbenzothiazoles and their biological activity

Autori
Ćaleta, Irena ; Karminski-Zamola, Grace ; Grdiša, Mira ; Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
13th European simposium on organic chemistry : programme & abstracts / Šunjić, Vitomir - Zagreb, 2003, 374-374

Skup
European simposium on organic chemistry (13 ; 2003)

Mjesto i datum
Cavtat, Hrvatska; Dubrovnik, Hrvatska, 10.09.2003. - 15.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
styrylbenzothiazoles; amidines; biological activity

Sažetak
A large number of benzothiazole derivatives are of considerable biological and chemical interest. Their pharmaceutical and agrochemical applications are of particular relevance. In order to find a new biologically active benzothiazole compounds we prepared in the multistep synthesis a serie of new styrylbenzothiazole compounds 1-9 starting from 6-cyano-2-methylbenzothiazole or 2-methylbenzothiazole and corresponding benzaldehydes. Cyano-derivatives of styrylbenzothiazoles 1-3 were converted by Pinner reaction into the corresponding amidine hydrochlorides 4-9. All styrylbenzothiazole compounds were tested on their antitumor activity. All compounds were characterized by means of IR, 1H- and 13C-NMR spectroscopy and elemental analysis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA