Naslov
Synthesis, photochemical synthesis and antitumor activity of new amidino substituted benzo[b]thieno quinolones

Autori
Jarak, Ivana ; Kralj, Marijeta ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th European symposium on organic chemistry : programme & absrtacts / Šunjić, Vitomir - Zagreb, 2003, 377-377

Skup
13th European symposium on organic chemistry

Mjesto i datum
Cavtat, Hrvatska; Dubrovnik, Hrvatska, 10.09.2003. - 15.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
benzo[b]thienoquinolones; amidines; photochemical dehydrohalogenation

Sažetak
Quinolones have found many uses in medicinal and synthetic chemistry. Some of them possess interesting biological and pharmacological activities, such as antibacterial, antiasthmatic, antivirial and antitumor activity. New amidino- and bis- amidino- subsituted benzo[b]thienoquinolones 1-9 were prepared by multistep synthesis. Bis- and mono- amidino- supstituted anilides, obtained from corresponding cyano-anilides by Pinner reaction or by condensation of acyl-chlorides with p-amino-N(isopropyl)benzoamidine, were photochemicaly dehydrohalogenated in methanolic or aqueos solution to obtain quinolones. All prepared compounds were tested on their antitumor activities.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA