Naslov
Photochemical reactions of 2-styryl-6-substituted-amidino-benzimidazoles as hydrochloride salts

Autori
Hranjec, Marijana ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th European symposium on organic chemistry : programe & abstracts / Vitomir Šunjić, Vitomir - Zagreb, 2003, 378-378

Skup
European symposium on organic chemistry (13 ; 2003)

Mjesto i datum
Dubrovnik, Hrvatska; Cavtat, Hrvatska, 10.09.2003. - 15.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
benzimidazolo[3; 2-a]quinolines; amidines; photochemistry

Sažetak
The compounds in title 1a, b-4a, b were prepared in the reaction of corresponding cinnam-aldehyde with 4-amidino-substituted-o-phenylenediamines. Compounds 1a, b-4a, b were irradiated in different solvents and different photoproducts were isolated according to the Scheme 1 : In ethanolic solution (c=1.3X10-2M) photochemical dehydrocyclization reaction took place, and corresponding amidino-substituted-benzimidazolo[3, 2-a]quinolines as hydrochloride salts 5-8 were isolated. When the photochemical reaction was performed in the water solution (c=1.3X10-2M), only dimeric products of [2+2] cycloadition reaction, 9a, b-12a, b, were isolated. Benzimidazolo[3, 2-a]quinolines exhibit antineoplastic activities and act as intercalators on DNA or inhibitors of topoisomerase II. Amidino and diamidino substituted heterocyclic compounds exhibit antitumor activity, and serve as intercalators or “ groove binders” .

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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