Naslov
Immunogenetic profile of guttate psoriasis in Croatian patients

Autori
Pašić, Aida ; Grahovac, Blaženka ; Lipozenčić, Jasna ; Dražić, Vesna ; Čeović, R ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 9th International psoriasis symposium / Roenigk, Henry H ; Maibach, Howard I. - New York (NY) : SDEF Skin Disease Education Foundation, 2003

Skup
The 9th international psoriasis symposium

Mjesto i datum
Sjedinjene Američke Države, 18.06.2003. - 22.06.2003

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
psorijaza; imunogenetski profil; HLA geni
(Psoriasis guttate; immunogenetic profile; HLA genes)

Sažetak
Psoriasis is heterogenous disease in its clinical expression. Guttate psoriasis is a well defined form of psoriasis characterized by widespread eruption of small red scaly lesions, classically in association with beta-hemolytic streptococcal infection. The eruption typically follows streptoccocal pharyngitis in 1-3 weeks. The role of streptococcal infection in chronic plaque psoriasis is less certain. Twenty-three patients (7 male and 16 female) with guttata psoriasis were typed for HLA class I and II using low resolution Biotest-SSP kits.Control group consisted of 190 unrelated healthy blood donors. The frequencies of HLA B13(OR=21.93, p<0, 001), B37 (OR=52.5, p<0, 001), Cw*06 (OR=138, 76, p<0, 001), DRB1*0701 (OR=7, 54, p<0, 001) and DQA1*0201(OR=8, 99, p<0, 001) were significantly increased in guttate psoriasis patients as compared with the control.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA