Naslov
To drink or not to drink:How are alcohol, caffeine and past smoking related to bone mineral density in elderly women
(To drink or not to drink:How are alcohol, caffeine and past smoking related to bone mineral density in elderly women.)

Autori
Ilich, JZ ; Brownbill, RA ; Tamborini, L ; Crncevic Orlic, Z

Izvornik
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (0731-5724) 21(6) (2003), 6; 536 - 544

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone mineral density; Calcium Alcohol; Caffeine; Past smoking; Postmenopausal
(Bone mineral density; Calcium; Alcohol; Caffeine; Past smoking; Postmenopausal)

Sažetak
Objectives:to determinr relationship between alcohol, cafeine, past smoking and bone mineral density of different skeletal sites in elderly women, accounting for other biological and life-style variables. Methods/Design:A cross-sectional study in 136 Caucasian women, mean +/- SD age 68.6 +/-7.1 years, all healthy and free of medications affecting bones, including estrogen.Bone mineral density(BMD)of multiple skeletal regions and body composition were measured by dual X ray aabsorptometry.Serum vitamin D(25-OHD)and parathyroid hormone(PTH) were analysed and used as confounders.Calcium(Ca)intake was assessed by food frequency questionnaire.Alcohol and caffeine consumption was determining frequency, amount and source of each.There were no current smokers, but the history of smoking wos recorded, including number of years and packages smoked/day.Past physical activity was considered at p less than or equal to 0, 05. Results: In the correlational analysis, alcohol was positively associated with spine BMD (r=0.197, p=0.02). 25-OHD and negativelywith PTH. Smoking was negatively related to Ca intake, 2.5(OH)D and number of reproductive years. In subgroup (stratified by Ca intake)and multiple regression analyses, alcohol (average similar to 0.5-1 drinks/day or similar to 8 g alcohol /day) was favorably associated with BMD of spine and total body. Caffeine (average similar to 2.5 6-fl oz cups/ day or 200-300mg caffeine/ day) had negative association with most of the skeletal sites, which was attenuated with higher Ca intake (greater than or equal to median, 750mg/day ). The past smokers who smoked on average 24years of similar to 1 pack cigarettes/day had lower BMD in total body, spine and femur than never-smokers when evaluated in subgroup analyses, and the association was attenuated in participants with greater than or equal to median Ca intake. There was no significant association between past smoking and BMD of any skeletal site in multiple regression analyses. Conclusion:The results support the notion that consumption of small/moderate amound of alcohol is positively, while caffeine and past smoking are negatively associated with most of the skeletal sites, which might be attenuated with Ca intake above 750mg/day

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA