{\rtf1\ansi\ansicpg1252\uc1 \deff27\deflang1033\deflangfe1033{\fonttbl{\f0\froman\fcharset0\fprq2{\*\panose 02020603050405020304}Times New Roman;}{\f27\fswiss\fcharset0\fprq2{\*\panose 020b0604030504040204}Verdana;} {\f173\froman\fcharset238\fprq2 Times New Roman CE;}{\f174\froman\fcharset204\fprq2 Times New Roman Cyr;}{\f176\froman\fcharset161\fprq2 Times New Roman Greek;}{\f177\froman\fcharset162\fprq2 Times New Roman Tur;} {\f178\froman\fcharset177\fprq2 Times New Roman (Hebrew);}{\f179\froman\fcharset178\fprq2 Times New Roman (Arabic);}{\f180\froman\fcharset186\fprq2 Times New Roman Baltic;}{\f389\fswiss\fcharset238\fprq2 Verdana CE;} {\f390\fswiss\fcharset204\fprq2 Verdana Cyr;}{\f392\fswiss\fcharset161\fprq2 Verdana Greek;}{\f393\fswiss\fcharset162\fprq2 Verdana Tur;}{\f396\fswiss\fcharset186\fprq2 Verdana Baltic;}}{\colortbl;\red0\green0\blue0;\red0\green0\blue255; \red0\green255\blue255;\red0\green255\blue0;\red255\green0\blue255;\red255\green0\blue0;\red255\green255\blue0;\red255\green255\blue255;\red0\green0\blue128;\red0\green128\blue128;\red0\green128\blue0;\red128\green0\blue128;\red128\green0\blue0; \red128\green128\blue0;\red128\green128\blue128;\red192\green192\blue192;}{\stylesheet{\ql \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs20\lang2057\langfe1033\cgrid\langnp2057\langfenp1033 \snext0 Normal;}{ \s1\qj \li0\ri0\keepn\widctlpar\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0 \i\f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 \sbasedon0 \snext0 heading 1;}{\*\cs10 \additive Default Paragraph Font;}{ \s15\ql \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 \sbasedon0 \snext15 Body Text;}{\s16\qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 \sbasedon0 \snext16 Body Text 2;}{\s17\qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs20\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 \sbasedon0 \snext17 Body Text 3;}}{\info{\title ELEKTRONSKO-MIKROSKOPSKA ANALIZA SPERMIJA U PACIJENATA S OLIGOASTENOSPERMIJOM}{\author Davor Je\'9eek}{\operator Davor Je\'9eek}{\creatim\yr2003\mo4\dy3\hr23\min53}{\revtim\yr2003\mo4\dy5\hr18\min42} {\printim\yr2003\mo4\dy5\hr18\min41}{\version4}{\edmins4}{\nofpages1}{\nofwords250}{\nofchars1624}{\*\company Medical School University of Zagreb}{\nofcharsws0}{\vern8247}}\paperw11906\paperh16838\margl1701\margr1701\margt1134\margb1417 \widowctrl\ftnbj\aenddoc\makebackup\noxlattoyen\expshrtn\noultrlspc\dntblnsbdb\nospaceforul\hyphcaps0\formshade\horzdoc\dghspace180\dgvspace180\dghorigin1701\dgvorigin1984\dghshow0\dgvshow0 \jexpand\viewkind1\viewscale100\pgbrdrhead\pgbrdrfoot\nolnhtadjtbl \fet0\sectd \psz9\linex0\endnhere\sectdefaultcl {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang{\pntxta .}}{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang{\pntxta .}}{\*\pnseclvl3 \pndec\pnstart1\pnindent720\pnhang{\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang{\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}} {\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}\pard\plain \s15\qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 {\f0 ELEKTRONSKO-MIKROSKOPSKA ANALIZA SPERMIJA U PACIJENATA S OLIGOASTENOSPERMIJOM \par }\pard\plain \qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs20\lang2057\langfe1033\cgrid\langnp2057\langfenp1033 {\b\f0\lang1050\langfe1033\langnp1050 \par }{\b\f0\lang1050\langfe1033\langnp1050 Je\'9eek D}{\f0\lang1050\langfe1033\langnp1050 .}{\f0\lang1050\langfe1033\super\langnp1050 1}{\f173\lang1050\langfe1033\langnp1050 , Cvitkovi\'e6 P.}{\f0\lang1050\langfe1033\super\langnp1050 2}{ \f173\lang1050\langfe1033\langnp1050 , \'c8}{\f0\lang1050\langfe1033\langnp1050 olak B.}{\f0\lang1050\langfe1033\super\langnp1050 2}{\f0\lang1050\langfe1033\langnp1050 \par \par }{\f0\lang1050\langfe1033\super\langnp1050 1}{\f173\lang1050\langfe1033\langnp1050 Sveu\'e8ili\'9ate u Zagrebu, Medicinski fakultet, Zavod za histologiju i embriologiju; }{\f0\lang1050\langfe1033\super\langnp1050 2}{\f173\lang1050\langfe1033\langnp1050 Sveu\'e8ili\'9ana klinika \'abVuk Vrhovac\'bb, Zagreb, Hrvatska \par }{\f0\lang1050\langfe1033\langnp1050 \par }\pard\plain \s1\qj \li0\ri0\keepn\widctlpar\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0 \i\f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 {\f0\fs20 Cilj rada \par }\pard\plain \s16\qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 {\f0\fs20 Cilj na\'9a eg rada bio elektronsko-mikroskopski analizirati ejakulat pacijenata kod kojih je prethodna }{\f173\fs20 androlo\'9aka obrada i ra\'e8unalna analiza ejakulata pokazala da se radi o te\'9akom poreme\'e6aju u morfologiji ili/i kinetici spermija. \par }{\f0\fs20 \par }\pard\plain \s1\qj \li0\ri0\keepn\widctlpar\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0 \i\f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 {\f0\fs20 Ispitanici i metode \par }\pard\plain \qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs20\lang2057\langfe1033\cgrid\langnp2057\langfenp1033 {\f0\lang1050\langfe1033\langnp1050 Tijekom 2002. godine analiziran je ejakulat 12 neplodnih pacijenata kod kojih je detaljna androlo\'9aka obrada }{\f173\lang1050\langfe1033\langnp1050 pokazala da se radi o te\'9akom poreme\'e6 aju morfologije ili/i kinetike spermija. Kontrolna skupina od 5 ispitanika imala je normospermiju. Ultrastrukturna analiza na\'e8injena je uz pomo\'e6 transmisijskog elektronskog mikroskopa Carl Zeiss 902A (Centar za elektrons}{ \f0\lang1050\langfe1033\langnp1050 ku mikroskopiju Medicinskog fakulteta u Zagrebu). \par \par }\pard\plain \s1\qj \li0\ri0\keepn\widctlpar\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0 \i\f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 {\f0\fs20 Rezultati \par }\pard\plain \s17\qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs20\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 {\f173 U ve\'e6ini slu\'e8 ajeva (n=8) radilo se o anomalijama glave spermija ili su one bile kombinirane s anomalijama repa. U jednom broju uzoraka mogao se primjetiti nedovoljno zgusnuti kromatin te membrans ke inkluzije unutar same jezgre spermija. U 2 pacijenta glava spermija je imala izraziti globularni oblik. Akrosom je u skupini neplodnih pacijenata \'e8esto bio poreme\'e6ene gra\'f0e (akrosom u obliku akrosomskog zrnca, neobi\'e8no izdu\'9e eni akrosom dislociran u rezidualnom tjele\'9acu i sl.). U 6 slu\'e8ajeva mogao se dijagnosticirati poreme\'e6aj u gra\'f0i repa spermija. U jednom slu\'e8aju radilo se o poreme\'e6aju mikrotubula (\'absuvi\'9ani\'bb mikrotubul), dok su u ostalih pacijenata mitohondriji u po\'e8etnom dijelu repa bili nedovoljno s}{\f0 piralizirani ili se nalazili u sastavu ostatnog tjele\'9aca. \par }\pard\plain \qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs20\lang2057\langfe1033\cgrid\langnp2057\langfenp1033 {\f0\lang1050\langfe1033\langnp1050 \par }\pard\plain \s1\qj \li0\ri0\keepn\widctlpar\aspalpha\aspnum\faauto\outlinelevel0\adjustright\rin0\lin0\itap0 \i\f27\fs24\lang1050\langfe1033\cgrid\langnp1050\langfenp1033 {\f173\fs20 Zaklju\'e8ak \par }\pard\plain \qj \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \f27\fs20\lang2057\langfe1033\cgrid\langnp2057\langfenp1033 {\f173\lang1050\langfe1033\langnp1050 Elektronsko-mikroskopska analiza spermija mo\'9e e dati vrijedne podatke o poreme\'e6ajima ultrastrukturne gra\'f0e ovih stanica te bitno razjasniti uzroke neplodnosti u mu\'9akarca.}{\f0\lang1050\langfe1033\langnp1050 \par \par \par }}