Pregled bibliografske jedinice broj: 134078
Spectrophotometric determination of dissociation constants of the two oxime groups of 1, 1'-bis(pyridinium-4-aldoxime)trimethylene dibromide
Spectrophotometric determination of dissociation constants of the two oxime groups of 1, 1'-bis(pyridinium-4-aldoxime)trimethylene dibromide // Book of Abstracts: 10th European Conference on the Spectroscopy of Biological Molecules / Szalontai B., Kota Z. (ur.).
Segedin: Institute of Biophysics Biological Research Centre, Hungarian Academy of Scinces, 2003. str. 108-108 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Spectrophotometric determination of dissociation constants of the two oxime groups of 1, 1'-bis(pyridinium-4-aldoxime)trimethylene dibromide
Autori
Foretić, Blaženka ; Burger, Nicoletta
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Book of Abstracts: 10th European Conference on the Spectroscopy of Biological Molecules
/ Szalontai B., Kota Z. - Segedin : Institute of Biophysics Biological Research Centre, Hungarian Academy of Scinces, 2003, 108-108
Skup
10th European Conference on the Spectroscopy of Biological Molecules
Mjesto i datum
Szeged, Mađarska, 30.08.2003. - 04.09.2003
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
1; 1’; -Bis(pyridinium-4-aldoxime)trimethylene dibromide; Dissociation constants; Spectrophotometry
Sažetak
The dissociation constants of the two oxime groups of 1, 1&#8217 ; ; -bis(pyridinium-4-aldoxime)trimethylene dibromide (TMB-4), a potent reactivator of the acetylcholinesterase inhibited by organophoshorus poisons, were determined from spectrophotometric data. Two numerical methods were used to treat the existing overlapping equilibria. The obtained results were in good agreement and their mean values at 25 oC corrected for the ionic strength of 0.05 M are pKa1 = 7.49 and pKa2 = 8.96. These values are discussed in terms of the pKas of 1, 1&#8217 ; ; -bis(pyridinium 4-aldoxime)oxydimethylene dichloride (Toxogonin), a similar dioxime, also known as an acetylcholinesterase reactivator, which were derived by extrapolation of literature data.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
