Pregled bibliografske jedinice broj: 133864
Investigation of the antimutagenic effect of Cruciferae vegetables on bacterial test systems and human cell lines
Investigation of the antimutagenic effect of Cruciferae vegetables on bacterial test systems and human cell lines // Book of abstracts 32nd Annual Meeting of European Environmental Mutagen Society
Varšava, 2002. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 133864 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Investigation of the antimutagenic effect of Cruciferae vegetables on bacterial test systems and human cell lines
Autori
Durgo, Ksenija ; Osmak, Maja ; Garaj-Vrhovac, Verica ; Franekić Čolić, Jasna
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Book of abstracts 32nd Annual Meeting of European Environmental Mutagen Society
/ - Varšava, 2002
Skup
32nd Annual Meeting of European Environmental Mutagen Society
Mjesto i datum
Varšava, Poljska, 03.10.2002. - 07.10.2002
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Cruiferae family; Salmonella typhimurium; Indole-3-carbinol
Sažetak
Glucosinolates are group of compounds widely distributed among the plants of Cruciferae family. These compounds are easily hydrolysed by the enzyme myrosinase which becomes activated after mechanical drstruction of the plant cells. Isothiocyanates, nitriles, thiocyanates and indole compounds are the most common products of such hydrolysis. In our previous report we have shown that there was no cytotoxic and mutagenic effect of indole-3-carbinol and cauliflower extract on wo bacterial test systems, Salmonella typhimurium, strains TA98 and TA100. In this work we have examined potential inhibitory effect of both compounds against two standard mutagens, 2-aminoantrachene and 4-nitroquinoline-1-oxide. It was estimated that simultaneous treatment of bacterial cells with mutagen and indole compound leads to a significiant inhbition of prototrofic growth. Indole compounds didn't inhibit the activity of P-glycoprotein in parental laryngeal carcinoma cells (HEp") and their cisplatin resistant subline (CK2). Indole compounds caused significant increase of glutathione level and glutathione-S-transferase activity in HEp2 cells . On the contrary, in CK2 cells which have uncreased basal level of glutathione, both drugs decreased the level of glutathione and glutathione-S-transferase activity. Indole-3-carbinol and cauliflower extract didn't cause any aberrant event in human lympocytes.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija
POVEZANOST RADA
Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb
