Naslov
D6S273 and MIB Polymorphisms in patients with psoriatic arthritis

Autori
Grubić, Zorana ; Perić, Porin ; Štingl, Katarina ; Čečuk-Jeličić, Esma ; Žunec, Renata ; Ćurković, Božidar ; Brkljačić-Kerhin, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the .... ; u: Genes and immunity 4 (2003) (S1) ; Poster Group 9 - Immunogenetics of Disease ; S32-S45 ; P173 / - , 2003, S44-S44

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
psoriatic arthritis; D6S273; MIB

Sažetak
Psoriatic arthritis (PsA), inflamatory arthritis followed by psoriasis, is related with B13, 27, 37, 38, 39, and 57 antigenes at HLA-B locus in Caucasians. We investigated polymorphism of 2 microsatellites in proximity of HLA-B locus (D6S273 and MIB) to prove whether additional genetic markers also increase disease susceptibility. Fifthy-five unrelated PsA patients, fullfiling criteria of disease and 165 controls were studied. Molecular typing of HLA-A, -B, Cw, and DRB1 alleles was performed by PCR-SSP. Microsatellites were analysed by electrophoresis on polyacrilamide gel (ALF express). From this study we concluded: (1) the frequency of HLA-B*13, *27, *39, and *57 alleles was largely increased in PsA ; (2) Cw*02 allele showed a slight association with the disease, while Cw*0602 did not show association with PsA ; (3) at DRB1 locus we did not find significantly increased frequency of DRB1*04 and *0701 in PsA ; (4) no significant differences of D6S273 and MIB alleles between PsA and controls were found ; (5) reassessment of results after the patients were divided into 2 groups based on presence or absence of one of above mentioned HLA-B alleles, showed significantly lower frequency of allele 130bp and 136bp at D6S273 locus in PsA, as well as for 346bp at MIB ; (6) higher frequency of D6S273 132bp and 134bp is due to linkage disequilibrium with B locus.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Doi: 10.1038/sj.gene.6363994

POVEZANOST RADA