Naslov
Acute effect of monoamine oxidase inhibitors on the 5-HT synthesis rate in the rat brain: An autoradiographic study
(Acute effect of monoamine oxidase inhibitors on the 5-HT synthesis rate on the rat brain: An autoradiographic study)

Autori
Muck-Šeler, Dorotea ; Diksic, Mirko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum Biologorum, Vol. 99, Suppl 1 / Vitale, Branko - Zagreb : IGP Štefanović, 1997

Skup
Second Croatian Congress of Pharmacology with International Participation

Mjesto i datum
Rijeka, Hrvatska, 09.09.1997. - 13.09.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
clorgyline; 5-HT synthesis rate; autoradiography; rat brain; deprenyl

Sažetak
The effect of acute administration of clorgyline ( a selective inhibitor of monoamine oxidase / MAO/ type A) and deprenyl (a selective inhibitor of MAO type B) on the serotonin (5-HT) synthesis rate, was determined in 28 regions of the rat brain using an autoradiographic method and 14C-alpha-methyl-L-tryptophan as a tracer. Results indicated that MAO inhibitors have different effects on the 5-HT synthesis rate in different brain regions. Clorgyline (10 mg/kg) and deprenyl (30 mg/kg) decreased 5-HT synthesis rate in the areas of nerve cell bodies i.e. in dorsal (-18 percent and -20 percent), median (-27 percent and -41 percent) raphe nuclei as well as in pineal body (-31 percent and -71 percent). Clorgyline increased 5-HT synthesis rate in sensory-motor cortex (37 percent), lateral caudate (37 percent) and ventral hippocampus (36 percent). In contrast, deprenyl did not induce significant changes in 5-HT synthesis rate in nerve terminals. Results suggest that the MAO activity participates in the regulation of 5-HT synthesis rate in the areas of cell bodies as well as in the nerve terminals. Research supported in part by the NIH and MRC grants.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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