Naslov
Seasonal influence on platelet 5-HT levels in patients with recurrent major depression and schizophrenia

Autori
Jakovljević, Miro ; Muck-Šeler, Dorotea ; Pivac, Nela, Ljubičić, Đulijano ; Bujas, Maja ; Dodig, Goran

Izvornik
Biological psychiatry (0006-3223) 41 (1997), 10; 1028-1034

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Platelet 5-HT;seasonal variations; recurrent major depression; schizophrenia; subtypes

Sažetak
The influence of seasons on platelet serotonin (5-HT) concentration was determined in 88 unipolar depressed and 117 schizophrenic male patients, and 90 normal male controls. Platelet 5-HT concentrations showed moderate, but insignificant intragroup seasonal variations in healthy controls and in the groups of depressed (psychotic and nonpsychotic) and schizophrenic (positive and negative) patients. In spring, platelet 5-HT concentrations were higher in schizophrenic patients than in normal controls or in depressed patients, while in other seasons platelet 5-HT concentrations were not significantly different between the groups. Higher platelet 5-HT concentrations were detected in psychotic when compared to nonpsychotic depressed patients in summer, fall, and winter Increased platelet 5-HT concentrations observed in schizophrenic patients with positive symptomes clearly separated these patients from patients with negative schizophrenia, especially in spring, summer and fall. Our results indicate the necessity to march patients with regard to the season of the sampling, and to divide depressed and schizophrenic patients into subtypes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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