Naslov
The SBASE domain sequence library, release 10: domain architecture prediction

Autori
Vlahoviček, Kristian ; Kaján, Laszló ; Murvai, János ; Hegedus, Zoltán ; Pongor, Sándor

Izvornik
Nucleic acids research (0305-1048) 31 (2003), 1; 403-405

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Protein Databases; Protein sequence; Domain Architecture; Domain Prediction

Sažetak
SBASE (http://www.icgeb.trieste.it/sbase) is an on-line collection of protein domain sequences and related computational tools designed to facilitate detection of domain homologies based on simple database search. The 10th 'jubilee release' of the SBASE library of protein domain sequences contains 1 052 904 protein sequence segments annotated by structure, function, ligand-binding or cellular topology, clustered into over 6000 domain groups. Domain identification and functional prediction are based on a comparison of BLAST search outputs with a knowledge base of biologically significant similarities extracted from known domain groups. The knowledge base is generated automatically for each domain group from the comparison of within-group ('self') and out-of-group ('non-self') similarities. This is a memory-based approach wherein group-specific similarity functions are automatically learned from the database.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA