Naslov
Trends in Pulmonary Function in Type 1 Diabetic Patients with Nephropathy

Autori
BOŽEK, Tomislav ; LJUBIĆ, Spomenka ; PAVLIĆ-RENAR, Ivana ; METELKO, Željko ; CAR, Nikica

Izvornik
Diabetologia. Supplement (Berlin) (0941-5602) 46 (2003);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
pulmonary function; diabetic nephropathy

Sažetak
Background and Aims: The abnormalities in small blood vessels have also been described in the lungs of patients with diabetes mellitus. The aim of this study was to assess the presence of pulmonary function abnormalities in patients with diabetes mellitus and verify possible association with renal microangiopathy. Materials and Methods: Forty type 1 diabetic patients (19 male and 21 female ; age: 44 9.09 years ; diabetes duration: 16 12.03 years) without overt lung disease and with no history of smoking were studied. Stepwise regression method was used to analyze the influence of predictor variables: patient’ s age, diabetes duration, systolic (SBP) and diastolic blood pressure, protein excretion rate (PER), serum creatinine, creatinine clearance, lipid values, glycated haemoglobin, body mass index and C-peptide level on diffusion capacity for carbon monoxide (DLCO), forced expiratory flow in the first second (FEV1), and forced expiratory flow when 50% of the forced vital capacity had been exhaled (FEF50). Results: DLCO correlated significantly with PER (p=0.0002), creatinine (p=0.011) and creatinine clearance (p=0.0009), but not with diabetes duration (p=0.146). After stepwise regression method PER was pointed out as the most important variable in the prediction of DLCO (R2=0.55), PER, RRS, and creatinine in the prediction of FEV1 (R2=0.38), and PER and diabetes duration in the prediction of FEF50 (R2=0.31). Significant difference (Mann-Whitney U test) was found between lung parameters: DLCO, FEF50, and FEV1 in the groups of patients with and without significant proteinuria (p=0.001 vs. p=0.001 vs. p=0.039). Conclusions: Pulmonary function abnormalities are common in patients with IDDM and signs of diabetic microangiopathy. This could be explained by impaired pulmonary microvasculature but also with pulmonary interstitial changes. PER was found to be the important variable in the prediction of DLCO, FEV1 and FEF50.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA