Naslov
Main predictors of renal resistance index in Type 2 diabetic patients

Autori
Ljubic, Spomenka ; Brkljacic, Boris ; Mesic, Ranko ; Metelko, Zeljko ; Pavlic-Renar, Ivana

Izvornik
Diabetologia. Supplement (Berlin) (0941-5602) 45 (2002);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
renal resistance; type 2 diabetics

Sažetak
Background and Aims: Diabetic nephropathy is a frequent microvascular complication in diabetic patients. Alterations in the vascular compartments result in the elevation of renal vascular resistance, manifested by the elevation of Doppler sonographic renal resistance index. The purpose of this study was to investigate the predictive variables for the elevation of the resistance index (RI) in the patients with type 2 diabetes. Materials and Methods: Fifty patients (24 males and 26 females ; age-range 39 to 71 years ; diabetes duration 0 to 25 years ; 24 with normoalbuminuria and 26 with microalbuminuria) were studied. Stepwise regression method was used to analyze the influence of predictor variables: patient's age, diabetes duration, systolic and diastolic blood pressure, albumin excretion rate (AER), Tamm-Horsfall protein excretion rate, lipid values, glycated hemoglobin, serum creatinine and creatinine clearance on the elevation of the resistance index. Results: Stepwise regression method showed that systolic blood pressure, disease duration and AER together explained nearly 53% of RI variance. Systolic blood pressure explained almost 24%, disease duration nearly 21% and AER nearly 8.5% of RI variance. In the group of normoalbuminuric patients (24 of 50) the elevation of RI was observed in 8 patients. Statistically significant difference was found in diabetes duration between normoalbuminuric patients with RI<0.70 and R&#61513 ; ; ; ; &#61486 ; ; ; ; &#61486 ; ; ; ; &#61486 ; ; ; ; &#61486 ; ; ; ; &#61472 ; ; ; ; 0.70 (p<0.05), but not in systolic blood pressure (p=1.000). In the group of normoalbuminuric, as well as microalbuminuric patients, a difference in RI according to the presence of tubular abnormalities was not observed (p=0.416 vs. p=0.631). Conclusion: Systolic blood pressure, diabetes duration and AER were found to be important variables in the prediction of RI. RI elevation might precede the occurrence of microalbuminuria. In spite of the correlation between AER and RI, other predictive variables were found to be more important in the prediction of RI. The importance of tubular abnormalities on RI elevation was not observed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA