Naslov
Stochastic Simulation of a Single Gene Cell Model

Autori
Kurtanjek, Želimir

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the 25-th International Conference on Information Technology Interfaces / Budin, Leo ; Lužar-Stiffler, Vesna ; Bekić, Zoran, Hljuz-Dobrić, Vesna - Zagreb : Sveučilišni računski centar Sveučilišta u Zagrebu (Srce), 2003, 489-495

Skup
Information Technology Interfaces

Mjesto i datum
Cavtat, Hrvatska, 16.06.2003. - 19.06.2003

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Cell model; stochastic simulation; metabolic control

Sažetak
Proposed is a generic single gene cell model as an extension of a &#8220 ; standard&#8221 ; single enzyme (Monod) model. The model is structured at three levels: 1) gene transcription, 2) enzyme synthesis, 3) metabolite and protein production. It accounts for a limiting substrate consumption, metabolite and biomass component production, gene transcription and enzyme synthesis. Assumed are control interactions between the key components at each level based on catalytic effects. Simulated is induction of gene transcription and enzyme synthesis as a cell response to step change of extracellular medium composition. In view of small number of key molecules stochastic simulation is applied.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA