Naslov
Induction of nitric oxide in vivo or in vitro by methionine-enkephalin

Autori
Balog, Tihomir ; Marotti, Tanja ; Mažuran, Renata ; Ročić, Boris ; Hršak, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum Biologorum 99 (suppl. 2), 1997 Annual Meeting of the Croatian Immunological Society / Vitale, Branko ; Rabatić, Sabina - Zagreb : Hrvatsko prirodoslovno društvo, 1997, 15-15

Skup
1997 Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Zagreb, Hrvatska, 06.11.1997. - 07.11.1997

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Met-enkephalin; nitric oxide; macrophages

Sažetak
Opioid peptides are known modulators of immune functions. The aim of this study was to investigated the ability of methionin enkephalin (MENK)to induce in vivo or in vitro nitric oxide release from macrophages. We also investigated wether this effect was direct, opioid receptor mediated or indirect trough inductions of cytokines. The obtained results demonstrated that various concentration of MENK had no effect of nitric oxide release in vitro, while in vivo this effect can be stimulatory or suppressive depend of used dose. The stimulative, but not suppressive effect could be abrogated by naloxone.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA