Naslov
Macrophage-derived nitric oxide induced in vivo or in vitro by methionine-enkephalin

Autori
Balog, Tihomir ; Marotti, Tanja ; Mažuran, Renata ; Ročić, Boris ; Hršak, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Immunology letters, Abstracts of the 13th European Immunology Meeting / Wagner, H. ; Heeg, K. ; Pfeffer K. - Oxford : Elsevier, 1997, 466-466

Skup
13th European Immunology Meeting

Mjesto i datum
Amsterdam, Nizozemska, 22.06.1997. - 25.06.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Met-enkephalin; nitric oxide; macrophages

Sažetak
Opioid peptides are known to modulate immune functions. In this study we have tested the ability of methionine enkephalin (MENK)to induce in vitro or in vivo the release of nitric oxides (NO) from naive or lipopolysaccharide (LPS)stimulated mouse peritoneal macrophages (PEM). We also investigated wether the effect was direct, (opioid receptor mediated) or indirect trough induction of cytokines or hypothalamic-pituitary-adrenal axis (HPA)activation. The obtained results demonstrated that various concentrations of MENK had in vitro no effect on NO release. In vivo only p.m. injection was effective, i.e. the 2.5mg/kg and 10mg/kg of MENK stimulated while 5.0mg/kg of MENK suppressed NO release. The stimulative, but not suppressive effect could be abrogated by naloxone.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA