Naslov
Effect of endosinusal treatment on cellular markers in mild and moderate asthmatics

Autori
Kalogjera, Livije ; Vagić, Davor ; Baudoin, Tomislav

Izvornik
Acta Otolaryngologica (Stockholm) (0001-6489) 123 (2003), 3; 310-313

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rhinosinusitis; eosinophil cationic protein; myeloperoxidase; sinus lavage; tryptase

Sažetak
The study was performed to test efficacy of topical endosinusal treatment on reduction of inflammatory cells activation and asthma/rhinosinuitis symptoms in patients with asthma and chronic rhinosinusitis (CRS). Eighteen mild to moderate asthmatics with chronic rhinosinusitis were subjected to antral sinoscopy and endosinusal treatment with 2 mg of dexamethasone and 40 mg of gentamycine per maxillary sinus during 7 days. Sinus lavage and serum samples were taken prior to and after the treatment and bacteriological swabs from the sinuses were taken at inclusion.Subjective scores for CRS symptoms and FEV1 were tested at inclusion and after 30 days. Eosinophil cationic protein (ECP), tryptase (try) and myeloperoxidase (MPO), were analyzed in serum and sinus fluid before and after the treatment. ECP and tryptase were significantly reduced both in serum and sinus fluid, but serum MPO did not show significant changes after the treatment. MPO in sinus lavage was reduced only in moderate asthmatics. Subjective scores for CRS and FEV1 were significantly reduced in the whole group. ECP, usually used as parameter for asthma staging, is mostly affected at systemic level, while tryptase is more markedly reduced at the local level. Topical endosinusal treatment used in this clinical study, significantly reduced activation of eosinophils and mastocytes, FEV1 and symptoms of CRS in mild/moderate asthmatics.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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