Naslov
Nitric oxide production by peritoneal macrophages induced by pentapeptide-dissaccharide from B. divaricatum and some of its derivatives

Autori
Balog, Tihomir ; Bogunović, Maja ; Vranešić, Branka ; Hršak, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Immunology letters, Abstracts of the 13th European Immunology Meeting / Wagner, H ; Heeg, K ; Pfeffer K. - : Elsevier, 1997, 440-440

Skup
13th European Immunology Meeting

Mjesto i datum
Amsterdam, Nizozemska, 22.06.1997. - 25.06.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
nitric oxide; peptidoglycans; immunmomodulation
(nitric oxide; peptidoglycans; immunomodulation)

Sažetak
Low molecular weight bacterial peptidoglycans like muramyl peptides are immunomodulators usually acting indirectly through activation of macrophages. They are generally less toxic but in the same time less potent than large bacterial cell wall fragments. Therefore, many derivatives of muramyl peptides have been constructed with the aim to inprove their activity. Here we present the data of the influence of one dissaccharide-pentapeptide from Brevibacterium divaricatum (PGM), its lypophilic (Na-Lauroil PGM) and metalo derivative (Fe-PGM) as well as two adamantyl-dipeptide stereoisomers (AdTP1 and AdTP2) on NO production by mouse peritoneal macrophages. PGM and its Na-lauroil derivative alone increased the production of NO by peritoneal macrophages, however less than LPS did. Fe-PGM and adamantyl dipeptides alone were ineffective. In combination with IFN both adamantyl dipeptides , but not PGM , expressed synergistic effect on the NO production (up to the level of LPS stimulatory effects.) In combination with LPS only one stereoisomere of adamantyl-dipeptide (AdTP2) showed synergistic stimulatory effect.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA