Naslov
Analysis of individual antibodies to HCV in HCVAg positive individuals

Autori
Burek, V. ; Mikulić, R.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book / 11th International Symposium on Viral Hepatitis and Liver Disease / Cossart, Yvone - Sydney : Australian Center for Hepatitis Virology, 2003, 226-226

Skup
11th International Symposium on Viral Hepatitis and Liver Disease

Mjesto i datum
Sydney, Australija, 06.04.2003. - 10.04.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Individual antibodies; HCVAg

Sažetak
Following the dynamics of appearing and disappearing of HCVAg in some of our patients with acute HCV infection we found simultaneous presence of HCVAg and anti-HCV mainly in a period when HCVAg were near disappearance (group 1). Beside that we found a simultaneous presence of HCVAg and anti-HCV in a number of patients with long persistence of anti-HCV (group 2). In the majority of cases with simultaneous presence of HCVAg and anti-HCV, spectrum of individual antibodies differed from that found in individuals with anti-HCV only (without HCVAg). We tried to analyse spectrum of individual antibodies to HCVAg in group 1 and 2 in more detail. A total of 45 sera 15 from group 1 and 30 from group 2 with simultaneous presence of HCVAg and anti-HCV were tested for individual antibodies to HCV.Control group comprised 50 sera of 50 patients without HCVAg and anti-HCV only.Anti-HCV: c100(p) were present in 61, 5% in group 1 and in 63, 2% in group 2 vs 100, 0% in control group ; c33c-100, 0%(group 1), 100, 0%(group 2), 98, 7% (control) ; c22(p)-45, 2% (group 1), 51, 8% (group 2), 100, 0% (control) ; NS5-33, 1% (group 1), 49, 7% (group 2), 95, 8% (control). These findings showed that spectrum of individual antibodies to HCVAg in both groups of patients with simultaneous presence of HCVAg and anti-HCV (acute HCV infection and individuals with long lasting HCV positivity) is more narrow than in control group (with anti-HCV but without HCVAg). Possible explanation for such differencies could be that slow appearance of some antibodies in the acute HCV infection (due to evolution of antibodies) enables detection of HCVAg for yet some period of time and disappearance of the same antibodies after a lng persistence directed to some HCVAg epitopes enables "reappearance" of HCVAg simultaneously with anti-HCV.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Veterinarska medicina

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