Naslov
Incidence of Acute Lower Respiratory Infections (ALRI) in Children under Five Years: I. Global Estimate

Autori
Rudan, Igor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the World Health Organization Meetings on Global Burden of Disease / Black, Robert ; Bryce, Jennifer) - Ženeva : WHO, 2002

Skup
World Health Organization Meeting on Global Burden of Disease

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 10.08.2002. - 14.08.2002

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ALRI; under-fives; developing countries; global incidence

Sažetak
Acute lower respiratory infections (ALRI) in children under five are still the leading cause of childhood mortality in the world. The WHO recently estimated the annual number of ALRI-related deaths at 2.1 million. In this paper we aim to estimate the incidence of ALRI in young children in developing countries, which is a close approximation of the global ALRI incidence. Our estimate is based on an analysis of published data on the ALRI incidence from community-based longitudinal studies. Among more than 2, 000 studies published since 1961, we identified 46 studies reporting ALRI incidence and 28 met pre-defined quality criteria. The median incidence estimate from those studies was 0.28 episodes per child-year (25% - 75% inter-quartile range 0.21-0.71). We assessed the plausibility of this estimate in two ways. The first approach was based on global ALRI mortality and reported case-fatality rates for (all) ALRI reported in community-based studies. This yielded a median incidence of 0.20 episodes per child-year (25% - 75% inter-quartile range 0.15-0.31). The second approach was based on global ALRI mortality, reported case fatality rate for severe cases only and estimated proportion of severe cases among all ALRI cases. This produced a median incidence of 0.44 episodes per child-year (25% - 75% inter-quartile range 0.28-0.76). These analyses suggest that the global ALRI incidence is close to 0.29 episodes per child-year in children under 5 years of age in developing countries. This equates to an annual incidence of 154 million new ALRI cases, 11-20 million (7-13%) of which are severe enough to require hospital admission.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA