Naslov
HOW EFFICIENT IS IONIZING RADIATION IN THE DEGRADATION OF PHARMACEUTICALS? A DOXAZOSIN STUDY

Autori
Tartaro Bujak, Ivana ; Pocrnić, Marijana ; Blažek, Kalo ; Bojanić, Krunoslav ; Trebše, Polonca ; Lebedev, Albert T. ; Galić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
32nd Miller Conference on Radiation Chemistry - Book of abstracts / - , 2023, 70-70

Skup
32nd Miller Conference on Radiation Chemistry

Mjesto i datum
Korzika, Francuska, 03.06.2023. - 08.06.2023

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
gamma irradiation, pharmaceuticals, doxazosin, wastewater

Sažetak
The high production and consumption of pharmaceuticals nowadays have resulted in their constant release into the environment. Environmental problems associated with pharmaceuticals are mainly due to their longevity and critical biological activity. It is well known that conventional wastewater treatment processes are not capable of completely removing them from wastewater. Therefore, new and more efficient methods need to be developed. Several studies have shown that ionizing radiation is a successful and cost-effective method for the degradation of a variety of pharmaceuticals [1, 2]. In this study, we focused on the radiation-induced degradation of doxazosin (DOX) [3], a widely used antihypertensive drug found in raw water. The efficiency of degradation was studied under different absorbed doses, dose rates, pH values and in the presence of radical scavengers and inorganic ions. Removal of 10 mg L−1 DOX reached almost 100 % at irradiation doses of 200 Gy regardless of the dose rate used. The effect of saturated solutions with N2, N2O, air and the addition of radical scavengers such as 2-PrOH and thiourea on DOX degradation was investigated. The efficiency of degradation increased in the order: thiourea < 2-PrOH < N2 < air < N2O. DOX degradation was favorable in the neutral, slightly acidic range (pH = 6.5) and decreased under acidic or alkaline conditions. Despite the strong degradation of DOX up to 200 Gy, much higher doses are required for the overall mineralization process. Samples irradiated with 500 Gy resulted in higher toxicity testing on V. fischeri bacteria than samples irradiated with lower doses. High- resolution quadrupole time-of-flight (QTOF) mass spectrometry was used for detection and characterization of degradation products. The structures of degradation products were determined based on MS and MSMS spectra, and degradation pathways were proposed under different experimental conditions. Overall, irradiation technology could be a promising technique for the removal of micropollutants, such as pharmaceuticals in real water matrices.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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