Naslov
Preclinical Models and Promising Pharmacotherapeutic Strategies in Liver Fibrosis: An Update

Autori
Kolaric, Tea Omanovic ; Kuna, Lucija ; Covic, Marina ; Roguljic, Hrvoje ; Matic, Anita ; Sikora, Renata ; Hefer, Marija ; Petrovic, Ana ; Mihaljevic, Vjera ; Smolic, Robert ; Bilic-Curcic, Ines ; Vcev, Aleksandar ; Smolic, Martina

Izvornik
Current Issues in Molecular Biology (1467-3045) 45 (2023), 5; 4246-4260

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
liver fibrosis ; hepatic stellate cells ; NAFLD

Sažetak
Liver fibrosis represents one of the greatest challenges in medicine. The fact that it develops with the progression of numerous diseases with high prevalence (NAFLD, viral hepatitis, etc.) makes liver fibrosis an even greater global health problem. Accordingly, it has received much attention from numerous researchers who have developed various in vitro and in vivo models to better understand the mechanisms underlying fibrosis development. All these efforts led to the discovery of numerous agents with antifibrotic properties, with hepatic stellate cells and the extracellular matrix at the center of these pharmacotherapeutic strategies. This review focuses on the current data on numerous in vivo and in vitro models of liver fibrosis and on various pharmacotherapeutic targets in the treatment of liver fibrosis.

Izvorni jezik
Engleski

POVEZANOST RADA