Naslov
Estimation of effective population size using genomic information: simulation and empirical evidence

Autori
Vostry, Lubos ; Vostra-Vydrova, Hana ; Hofmanova, Barbara ; Drzaic, Ivana ; Cubric Curik, Vlatka ; Gorjanc, Gregor ; Curik, Ino

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstract of International Conference Management of Animal and Plant Genetic Resources 2021 / - , 2021, 30-30

Skup
International Conference Management of Animal and Plant Genetic Resources 2021

Mjesto i datum
Tirana, Albanija, 19.11.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Effective population size ; Genomics ; Inbreeding ; Linkage Disequilibrium ; Livestock

Sažetak
Effective population size (Ne) is a key parameter in population genetics because it is functionally related to genetic drift or stochastic variation in gene frequency, inbreeding, and linkage disequilibrium. Several methods have been applied to livestock populations using high-throughput genomic information ("SNeP", "NeEstimator" and "GONE"), all based on linkage disequilibrium (NeLD). In this study, we used computer simulations and empirical data (horse and sheep) to analyse how well the different NeLD estimates approximate the inbreeding effective population size (Ne) estimated from pedigree, genomic information (runs of homozygosity) and true autozygosity. Our analyses have shown that the recently proposed method implemented in the software GONE reliably estimates Nel when the population is constant, while estimates based on runs of homozygosity are promising but need further improvement.

Izvorni jezik
Engleski

Znanstvena područja
Poljoprivreda (agronomija)

POVEZANOST RADA