Naslov
Dexmedetomidine in spinal anesthesia - worth it?

Autori
Bodulica, Bruna ; Ozegic, Ognjen ; Lijovic, Lada ; Pazur, Iva ; Hostic, Vedran ; Radocaj, Tomislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Anaesthesiology, Volume 40 | e- Supplement 61 | June 2023 / Samama, Charles M. - Hagerstown, NJ : Wolters Kluwer Health, Inc., 2023, 103 / - , 2023, 103-103

Skup
Euroanesthesia 2023

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 03.06.2023. - 05.06.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
spinal ; dexmedetomidin ; stariji ; hemodinamika
(spinal ; dexmedetomidine ; elderly ; hemodynamic)

Sažetak
Background and Goal of Study: Spinal anesthesia is a preferred method of anesthesia for lower limb surgery. Antinociceptive synergism between local anesthetics and opioids is well studied. Dexmedetomidine, selective alpha2-agonist, is relatively new as an intrathecal agent. The main goal of this study was to compare dexmedetomidine with opioids as adjuvant to spinal anesthesia, in terms of its ef fect on postoperative analgesia, as well as its ef fect on hemodynamic stability in elderly patients. Materials and Methods: Spinal anesthesia was performed on thirty ASA Grade II and III geriatric patients undergoing hip surgery. Before the procedure all patients received 500 mL of i.v. saline. Noninvasive blood pressure, heart rate and SpO2 were noted every 5 minutes. NRS(numeric rating scale) was assesed 2, 4, 6, 8, 10 and 12 hours af ter spinal block. Patients were randomly assigned into two groups: control group (n=15) received levobupivacaine by body height nomogram with 2.5 mcg (0.5 mL) of sufentanil, while subject group (n=15) received levobupivacaine by body height nomogram with 5 mcg of dexmedetomidine. Groups were compared by hemodynamic parameters(systolic pressure, pulse) and NRS score in early postoperative stage of recovery. Results and Discussion: Baseline patients’ characteristics were comparable in both groups. Analysis of hemodynamic data showed that incidence of hypotension, defined as systolic blood pressure lower than 90 mmHg, was not significantly dif ferent between groups. When comparing analgesic ef fect, dexmedetomidine showed significantly better analgesic ef fect than opioids 10 and 12 hours af ter spinal block (p=0.03 and p<0.01), as shown in figure 1. Results are expressed as mean value with p value of 0.05 considered significant.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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