Naslov
Prophylaxis of oral mucositis in patients treated with hematopoietic stem cell transplantation

Autori
Pomper, Ljiljana ; Ostojić, Alen ; Jakovac, Ruža ; Stužić, Vesna ; Zemljak, Sanela ; Vukelić, Mara ; Životić, Ivana ; Šikić, Ivanka ; Krpečanec, Marina ; Petković, Kata ; Farkaš, Milka ; Vukorepa, Zvjezdana ; Smiljanić, Marija ; Dubrović, Nevenka ; Blažević, Suzana ; Elez, Tanja ; Kvesić, Vedran ; Vrhovac, Radovan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
37th Annual Meeting of the European Group for Blood and Marrow Tranplantation and 27th Meeting of the EBMT Nurses Group / - - Bratislava : Trnava, 2011 : Bone Marrow Transplantation, 2011, 436-437

Skup
37th Annual Meeting of the European Group for Blood and Marrow Tranplantation and 27th Meeting of the EBMT Nurses Group

Mjesto i datum
Pariz, Francuska, 03.04.2011. - 06.04.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
oral mucositis ; hematopoietic stem cell transplantation

Sažetak
Background: Oral mucositis (OM) is a frequent side effect following hematopoietic stem cell transplantation (HSCT) consequences of which affect life quality of patients (pts). Objective: to determine frequency, intensity, duration and consequences of OM by testing effectiveness of standard OM monoprophylaxis in comparison with OM combination prophylaxis. Patients and methods: records from 25 consecutive pts enrolled in an ongoing prospective study (Table 1), treated with autologous (auto) HSCT (22) or allogeneic (allo) HSCT (3) from April until October 2010 were analyzed. Conditioning protocols were: HD- melphalan (7), Flu/Bu/ATG (2), Bu-Cy (2), BEAM (10) and BEAC (4). All pts received antibacterial and antifungal prophylaxis and allo HSCT pts, in addition, received antiviral prophylaxis. Pts are divided into 3 groups (sr, src and srg) based on randomly received OM prophylaxis: standard rinse (SR) (aqua redestilata, chlorhexidine, bicarbonate pulver), SR+Caphosol® and SR+Gelclair®, respectively. Data on frequency, duration and intensity of OM, pain in oral cavity and use of opioid analgetics were compared between these 3 groups. The grade of OM was evaluated according to the WHO scale. Results: 84% of pts (sr, src, srg = 100%, 70%, 86%, respectively) developed OM, 20% of them developping OM of WHO grade 3. Median duration of OM was 8 days (mean 9.76, range 1-33, SD 6.94) and median OM grade was 2 (mean 1.76, range 1-3, SD 0.83). Median in-hospital time from start of conditioning was 19 (mean 20.28, range 15-37, SD 4.91). 52% of pts experienced pain in oral cavity (sr, src, srg = 75%, 43%, 33%, respectively) and 28% were receiving opioid analgetics (sr, src, srg = 50%, 20%, 14%, respectively). Table 2 shows data for each group of pts. Conclusion: Prophylaxis of OM plays an important part in nursing practice and demands coordinated measures between physicians, nurses and patients. Our analysis shows that OM is more frequent and appears in more severe form in pts treated with monoprophylaxis than in those treated with combined prophylaxis. Patients treated with combined prophylaxis had less frequent oral cavity pain, and those who had it, experienced it in lower intensity. However, this is just a preliminary report of a study that is still in progress. Further research on a greater number of pts is warranted.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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