Naslov
Effectiveness of Hypertension Therapy by Using Fixed Combinations and Monocomponent Drugs—A Prospective Study from Croatia

Autori
Banić, Antonija ; Benković, Vanesa ; Knezevic, Aleksandar

Izvornik
Journal of Pharmacy and Pharmacology (2328-2150) 6 (2018), 4; 333-339

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hypertension, fixed -dose combinations, compliance, adherence, Croatia.

Sažetak
Purpose: Arterial hypertension is the leading risk mortality factor in the world according to the report by the World Health Organization. The aim of this research was to compare fixed-dose combination with free-drug combination therapy and prove that fixed-dose combination improve patient compliance and persistence, measuring blood pressure among hypertensive patients in a Croatian Adriatic city. Methods: The study included 202 patients, 101 women and 101 men, mean age 66.8 ± 9.4 with previous diagnosis of hypertension. Results: Mean blood pressure was 152.8 ± 18.8/87.3 ± 10.3 mmHg. Blood pressure control (≤ 140/90 mmHg) was achieved in 24.8% of patients, 13.9% of women and 10.9% of men. Mean blood pressure in the group with fixed-dose combination was 149.2 ± 17.9/86.2 ± 8.5 mmHg, and 156.7 ± 18.9/88.4 ± 11.8 mmHg in the group with free-drug combination therapy. Conclusions: Results suggest that blood pressure control was better in patients with fixed-dose combinations than in patients with free-drug combinations. Fixed-drug combination improved compliance and adherence in patients with antihypertensive therapy. Results of the study indicate that fixed-drug combination should be considered in patients with hypertension according to the guidelines

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Farmacija, Ekonomija

POVEZANOST RADA