Naslov
The role of neoadjuvant therapy of breast cancer today

Autori
Dedić Plavetić, Natalija ; Križić, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Libri oncologici / - , 2021, 5-6

Skup
14. HRVATSKI ONKOLOŠKI KONGRES

Mjesto i datum
Online, 22.04.2021. - 25.04.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Breast cancer, neoadjuvant therapy

Sažetak
Neoadjuvant therapy (NAT) in breast cancer (BC), refers to presurgical systemic therapy (PST) administered prior to definitive surgery. In this review we’ll discuss recent advances in NST according to breast carcinoma surrogate subtypes.Despite being initially adopted as downstaging therapy before surgery, neoadjuvant trials for early breast cancer have accelerated the investigation of novel anticancer agents allowing registration trials with shorter duration and fewer participants. The neoadjuvant phase 2 platform trial I-SPY 2 simultaneously tests multiple drugs across different breast cancer subtypes using adaptive randomization for assessment of drug efficacy. There are lot of efforts put into the development of effective biomarkers for predicting the early responses to NAT with intention to de-escalate NAT particularly through novel MRI biomarkers.

Izvorni jezik
Engleski

Znanstvena područja
Brodogradnja, Kliničke medicinske znanosti

POVEZANOST RADA