Pregled bibliografske jedinice broj: 1276122
Carcinogenic mycotoxins
Carcinogenic mycotoxins // Comprehensive toxicology, 3rd edition / McQueen, Charlene (ur.).
Oxford: Elsevier, 2018. str. 154-167
CROSBI ID: 1276122 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Carcinogenic mycotoxins
Autori
Domijan, Ana-Marija ; Peraica, Maja
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Comprehensive toxicology, 3rd edition
Urednik/ci
McQueen, Charlene
Izdavač
Elsevier
Grad
Oxford
Godina
2018
Raspon stranica
154-167
ISBN
9780081006016
Ključne riječi
mycotoxins ; ochratoxin A ; aflatoxin B1 ; fumonisin B1 ; public health
Sažetak
Mycotoxins are metabolites of molds considered to be a major risk factor affecting human and animal health. It is estimated that 25% of the world’s crop production is contaminated with mycotoxins. Mold contamination occurs extensively in fields and is particularly severe in tropical countries. Due to the worldwide trade of grains, exposure to mycotoxins is ubiquitous. The co-occurrence of mycotoxins is frequent in food and feed, because of frequent infection with several fungal strains simultaneously, while a particular fungal strain may produce different mycotoxins (Binder et al., 2007). Animals and humans are mostly exposed to mycotoxins by ingestion of contaminated food, although dermal and inhalation routes of exposure have been reported. Contamination by molds may be effectively stopped by pesticide use, but pesticides cannot eliminate the mycotoxins produced by molds before their application. There is no single method of mycotoxin elimination, and each method increases the cost of food production. Up to now, more than 300 mycotoxins have been identified that cause signs of toxicity in mammals (Fink-Gremmels, 1999). Diseases caused by mycotoxins are referred to as mycotoxicoses and outbreaks are more readily recognized in veterinary than in human medicine. Mycotoxicoses are caused mostly by ingesting high levels of mycotoxins, and they are seen more frequently in tropical countries, both in humans and in animals because of favorable climatic conditions for mycotoxins production and low level of food and feed control (Peraica et al., 1999). Children are more sensitive to mycotoxins and in tropical countries, they are exposed to them already in utero (Peraica et al., 2014). There are several mycotoxins suspected to be human carcinogens, but with the exception of aflatoxin B1 (AFB1), this has only been demonstrated in experimental animals. In order to define the safety factor that will be used in the calculation of an acceptable daily intake, it is important to know the exact mechanismof a mycotoxin’s carcinogenicity (Dirheimer, 2000).
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Farmacija
POVEZANOST RADA
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb