Naslov
Carcinogenic Mycotoxins

Autori
Domijan, Ana-Marija ; Peraica, Maja

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Reference Module in Biomedical Sciences

Urednik/ci
Caplan, Michael

Izdavač
Elsevier Science

Grad
Amsterdam

Godina
2014

Raspon stranica
1-10

ISBN
0128012382

Ključne riječi
mycotoxins ; ochratoxin A ; aflatoxin B1 ; fumonisin B1 ; public health

Sažetak
Mycotoxins are metabolites of molds considered to be a major risk factor affecting human and animal health. It is estimated that 25% of the world’s crop production is contaminated with mycotoxins. Mold contamination occurs extensively in fields and it is particularly severe in tropical countries. Due to world trade of grains, exposure to mycotoxins is ubiquitous. The co-occurrence of mycotoxins is frequent in food and feed, because of frequent infection with several fungal strains and particular fungal strain may produce different mycotoxins (Binder et al., 2007). Animals and humans are mostly exposed to mycotoxins by ingestion of contaminated food, although dermal and inhalation routes of exposure have been reported. The contamination by molds may be effectively stopped by pesticide use, but pesticides cannot eliminate mycotoxins produced before their application. There is no single method of mycotoxin elimination, and each method increases the cost of food production.Up to now there have been more than 300 mycotoxins identified that cause signs of toxicity in mammals (Fink-Gremmels, 1999). Diseases caused by mycotoxins are referred to as mycotoxicoses and outbreaks are more readily recognized in veterinary than in human medicine. Mycotoxicoses are caused mostly by ingestion of high levels of mycotoxins, and either in humans or in animals they are seen more frequently in tropical countries (Peraica et al., 1999). There are several mycotoxins suspected to be human carcinogens, but with the exception of aflatoxin B1 (AFB1) this has only been demonstrated in experimental animals. It is important to know by which mechanism a mycotoxin is carcinogenic in order to define the safety factor that will be used in the calculation of an acceptable daily intake (Dirheimer, 2000).

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Farmacija

POVEZANOST RADA