Naslov
Protective effects of dhea and dheas on sh-sy5y neuroblastoma cells and primary mouse neurons, exposed to aβ oligomers, hydrogen peroxide and oxygen-glucose deprivation, as in vitro models of dementia

Autori
Vuić, Barbara ; Nedić Erjavec, Gordana ; Nikolac Perković, Matea ; Tudor, Lucija ; Konjevod, Marcela ; Pivac, Nela ; Švob Štrac, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Virtual FENS Regional Meeting 2021 : Book of abstracts / - , 2021, 296-296

Skup
Virtual FENS Regional Meeting 2021

Mjesto i datum
Kraków, Poljska, 25.08.2021. - 27.08.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DHEA ; DHEAS ; Alzheimer´s disease ; vascular dementia ; primary mouse neurons ; SH-SY5Y cells

Sažetak
Neurosteroids dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), the most abundant steroids in human blood, are also synthesized de novo in the brain, where they participate in varios functions such as neural plasticity, learning, memory and behavior. Dementia is a syndrome of progressive cognitive decline, with Alzheimer´s disease (AD) and vascular dementia (VaD), as the most common forms. AD is neurodegenerative disorder characterized by the abnormal deposition of the amyloid β (Aβ) peptide and accumulation of neurofibrillary tangles, and is associated with multiple pathophysiologic mechanisms including apoptosis and oxidative stress. VaD is due to the reduced blood flow, resulting in insufficient supply of nutrients and oxygen to the brain, leading to an impairment of memory and cognitive functions. We have investigated potential neuroprotective effects of these neurosteroids in primary mouse neurons, as well as in the SH-SY5Y neuroblastoma cells. As in vitro models of AD and VaD, we have exposed these cells to the toxic Aβ oligomers, hydrogen peroxide (H2O2) inducing oxidative stress, or to the oxygen-glucose deprivation (OGD). The obtained results demonstrated the beneficial effects of DHEA and DHEAS treatment on the cell survival and viability, suggesting potential neuroprotective actions of these neurosteroids in AD and VaD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA