Naslov
Cellular parabiosis: impact of the cellular environment on phenotype expression

Autori
Pavlović, Nikola ; Budimir, Jelena ; Radman, Miroslav ; Trajković, Katarina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Genetics&Applications - An Aspiring Interdisciplinary Journal of Genetic Research, Volume 7, Number 2 (ABMBBIH Conference 2023) / Bajrović, Kasim ; Hadžiselimović, Rifat ; Čakar, Jasmina - Sarajevo, 2023, 82-82

Skup
International Conference of Biochemists and Molecular Biologists in Bosnia and Herzegovina - ABMBBIH

Mjesto i datum
Sarajevo, Bosna i Hercegovina, 18.05.2023. - 20.05.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cellular parabiosis ; aging ; UV radiation ; cellular communication

Sažetak
Aging is a complex physiological process characterized by a progressive loss in physiological function and the emergence of age- related diseases. Much of the contemporary aging research focuses on cell-autonomous processes such as oxidative stress and impaired proteostasis, which are thought to be responsible for age- related diseases. However, non-cell autonomous processes may also play a role in the development of age-related phenotypes. We named such an impact of the cellular environment on the expression of aberrant phenotypes “cellular parabiosis”. While the bystander effect – spreading of aberrant phenotypes from damaged cells to the surrounding intact cells – has been well described, it remains unknown how the healthy cells may influence the damaged, dying cells in their vicinity. In this study, we investigated how cells that are damaged by UV radiation behave in the presence of healthy cells compared to the damaged cells in monocultures. We found that the survival of damaged cells is significantly decreased when they are co-cultured with healthy cells and that this effect mostly depends on the unknown factors secreted by the healthy cells. The underlying mechanism of this phenomenon might be linked with the arrested transcriptomic response to UV radiation that we identified in the UV-treated cells grown in co-culture with intact cells. Such accelerated dismissal of damaged cells due to the surrounding healthy cells might be a natural mechanism for cleaning the tissues from dying cells which can act as sources of toxicity.

Izvorni jezik
Engleski

POVEZANOST RADA