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Identifying the Common Genetic Basis of Antidepressant Response

Pain, Oliver; Hodgson, Karen; Trubetskoy, Vassily; Ripke, Stephan; Marshe, Victoria S.; Adams, Mark J.; Byrne, Enda M.; Campos, Adrian I.; Carrillo-Roa, Tania; Cattaneo, Annamaria et al.
Identifying the Common Genetic Basis of Antidepressant Response // Biological Psychiatry Global Open Science, 2 (2022), 2; 115-126 doi:10.1016/j.bpsgos.2021.07.008 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1274307 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Identifying the Common Genetic Basis of Antidepressant Response

Autori
Pain, Oliver ; Hodgson, Karen ; Trubetskoy, Vassily ; Ripke, Stephan ; Marshe, Victoria S. ; Adams, Mark J. ; Byrne, Enda M. ; Campos, Adrian I. ; Carrillo-Roa, Tania ; Cattaneo, Annamaria ; Als, Thomas D. ; Souery, Daniel ; Dernovsek, Mojca Z. ; Fabbri, Chiara ; Hayward, Caroline ; Henigsberg, Neven ; Hauser, Joanna ; Kennedy, James L. ; Lenze, Eric J. ; Lewis, Glyn ; Müller, Daniel J. ; Martin, Nicholas G. ; Mulsant, Benoit H. ; Mors, Ole ; Perroud, Nader ; Porteous, David J. ; Rentería, Miguel E. ; Reynolds, Charles F. ; Rietschel, Marcella ; Uher, Rudolf ; Wigmore, Eleanor M. ; Maier, Wolfgang ; Wray, Naomi R. ; Aitchison, Katherine J. ; Arolt, Volker ; Baune, Bernhard T. ; Biernacka, Joanna M. ; Bondolfi, Guido ; Domschke, Katharina ; Kato, Masaki ; Li, Qingqin S. ; Liu, Yu-Li ; Serretti, Alessandro ; Tsai, Shih-Jen ; Turecki, Gustavo ; Weinshilboum, Richard ; McIntosh, Andrew M. ; Lewis, Cathryn M. ; Kasper, Siegfried ; Zohar, Joseph ; Souery, Daniel ; Montgomery, Stuart ; Albani, Diego ; Forloni, Gianluigi ; Ferentinos, Panagiotis ; Rujescu, Dan ; Mendlewicz, Julien ; Wray, Naomi R. ; Ripke, Stephan ; Mattheisen, Manuel ; Trzaskowski, Maciej ; Byrne, Enda M. ; Abdellaoui, Abdel ; Adams, Mark J. ; Agerbo, Esben ; Air, Tracy M. ; Andlauer, Till F.M. ; Bacanu, Silviu- Alin ; Bækvad-Hansen, Marie ; Beekman, Aartjan T.F. ; Bigdeli, Tim B. ; Binder, Elisabeth B. ; Bryois, Julien ; Buttenschøn, Henriette N. ; Bybjerg-Grauholm, Jonas ; Cai, Na ; Castelao, Enrique ; Christensen, Jane Hvarregaard ; Clarke, Toni-Kim ; Coleman, Jonathan R.I. ; Colodro-Conde, Lucía ; Couvy-Duchesne, Baptiste ; Craddock, Nick ; Crawford, Gregory E. ; Davies, Gail ; Deary, Ian J. ; Degenhardt, Franziska ; Derks, Eske M. ; Direk, Nese ; Dolan, Conor V. ; Dunn, Erin C. ; Eley, Thalia C. ; Escott-Price, Valentina ; Hassan Kiadeh, Farnush Farhadi ; Finucane, Hilary K. ; Foo, Jerome C. ; Forstner, Andreas J. ; Frank, Josef ; Gaspar, Héléna A. ; Gill, Michael ; Goes, Fernando S. ; Gordon, Scott D. ; Grove, Jakob ; Hall, Lynsey S. ; Hansen, Christine Søholm ; Hansen, Thomas F. ; Herms, Stefan ; Hickie, Ian B. ; Hoffmann, Per ; Homuth, Georg ; Horn, Carsten ; Hottenga, Jouke-Jan ; Hougaard, David M. ; Howard, David M. ; Ising, Marcus ; Jansen, Rick ; Jones, Ian ; Jones, Lisa A. ; Jorgenson, Eric ; Knowles, James A. ; Kohane, Isaac S. ; Kraft, Julia ; Kretzschmar, Warren W. ; Kutalik, Zoltán ; Li, Yihan ; Lind, Penelope A. ; MacIntyre, Donald J. ; MacKinnon, Dean F. ; Maier, Robert M. ; Maier, Wolfgang ; Marchini, Jonathan ; Mbarek, Hamdi ; McGrath, Patrick ; McGuffin, Peter ; Medland, Sarah E. ; Mehta, Divya ; Middeldorp, Christel M. ; Mihailov, Evelin ; Milaneschi, Yuri ; Milani, Lili ; Mondimore, Francis M. ; Montgomery, Grant W. ; Mostafavi, Sara ; Mullins, Niamh ; Nauck, Matthias ; Ng, Bernard ; Nivard, Michel G. ; Nyholt, Dale R. ; O’Reilly, Paul F. ; Oskarsson, Hogni ; Owen, Michael J. ; Painter, Jodie N. ; Pedersen, Carsten Bøcker ; Pedersen, Marianne Giørtz ; Peterson, Roseann E. ; Peyrot, Wouter J. ; Pistis, Giorgio ; Posthuma, Danielle ; Quiroz, Jorge A. ; Qvist, Per ; Rice, John P. ; Riley, Brien P. ; Rivera, Margarita ; Mirza, Saira Saeed ; Schoevers, Robert ; Schulte, Eva C. ; Shen, Ling ; Shi, Jianxin ; Shyn, Stanley I. ; Sigurdsson, Engilbert ; Sinnamon, Grant C.B. ; Smit, Johannes H. ; Smith, Daniel J. ; Stefansson, Hreinn ; Steinberg, Stacy ; Streit, Fabian ; Strohmaier, Jana ; Tansey, Katherine E. ; Teismann, Henning ; Teumer, Alexander ; Thompson, Wesley ; Thomson, Pippa A. ; Thorgeirsson, Thorgeir E. ; Traylor, Matthew ; Treutlein, Jens ; Trubetskoy, Vassily ; Uitterlinden, André G. ; Umbricht, Daniel ; Van der Auwera, Sandra ; van Hemert, Albert M. ; Viktorin, Alexander ; Visscher, Peter M. ; Wang, Yunpeng ; Webb, Bradley T. ; Weinsheimer, Shantel Marie ; Wellmann, Jürgen ; Willemsen, Gonneke ; Witt, Stephanie H. ; Wu, Yang ; Xi, Hualin S. ; Yang, Jian ; Zhang, Futao ; Arolt, Volker ; Baune, Bernhard T. ; Berger, Klaus ; Boomsma, Dorret I. ; Cichon, Sven ; Dannlowski, Udo ; de Geus, E.J.C. ; DePaulo, J. Raymond ; Domenici, Enrico ; Domschke, Katharina ; Esko, Tõnu ; Grabe, Hans J. ; Hamilton, Steven P. ; Hayward, Caroline ; Heath, Andrew C. ; Kendler, Kenneth S. ; Kloiber, Stefan ; Lewis, Glyn ; Li, Qingqin S. ; Lucae, Susanne ; Madden, Pamela A.F. ; Magnusson, Patrik K. ; Martin, Nicholas G. ; McIntosh, Andrew M. ; Metspalu, Andres ; Mors, Ole ; Mortensen, Preben Bo ; Müller-Myhsok, Bertram ; Nordentoft, Merete ; Nöthen, Markus M. ; O’Donovan, Michael C. ; Paciga, Sara A. ; Pedersen, Nancy L. ; Penninx, Brenda W.J.H. ; Perlis, Roy H. ; Porteous, David J. ; Potash, James B. ; Preisig, Martin ; Rietschel, Marcella ; Schaefer, Catherine ; Schulze, Thomas G. ; Smoller, Jordan W. ; Stefansson, Kari ; Tiemeier, Henning ; Uher, Rudolf ; Völzke, Henry ; Weissman, Myrna M. ; Werge, Thomas ; Lewis, Cathryn M. ; Levinson, Douglas F. ; Breen, Gerome ; Børglum, Anders D. ; Sullivan, Patrick F.

Izvornik
Biological Psychiatry Global Open Science (2667-1743) 2 (2022), 2; 115-126

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antidepressant response ; Depression ; Genetics ; GWAS ; MDD ; Polygenic score

Sažetak
Background: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success of previous genome-wide association studies has been limited by sample size. This study performs the largest genetic analysis of prospectively assessed antidepressant response in major depressive disorder to gain insight into the underlying biology and enable out-of-sample prediction. Methods: Genome-wide analysis of remission (n remit = 1852, n nonremit = 3299) and percentage improvement (n = 5218) was performed. Single nucleotide polymorphism-based heritability was estimated using genome-wide complex trait analysis. Genetic covariance with eight mental health phenotypes was estimated using polygenic scores/AVENGEME. Out-of-sample prediction of antidepressant response polygenic scores was assessed. Gene-level association analysis was performed using MAGMA and transcriptome-wide association study. Tissue, pathway, and drug binding enrichment were estimated using MAGMA. Results: Neither genome-wide association study identified genome-wide significant associations. Single nucleotide polymorphism-based heritability was significantly different from zero for remission (h 2 = 0.132, SE = 0.056) but not for percentage improvement (h 2 = -0.018, SE = 0.032). Better antidepressant response was negatively associated with genetic risk for schizophrenia and positively associated with genetic propensity for educational attainment. Leave-one-out validation of antidepressant response polygenic scores demonstrated significant evidence of out-of-sample prediction, though results varied in external cohorts. Gene-based analyses identified ETV4 and DHX8 as significantly associated with antidepressant response. Conclusions: This study demonstrates that antidepressant response is influenced by common genetic variation, has a genetic overlap schizophrenia and educational attainment, and provides a useful resource for future research. Larger sample sizes are required to attain the potential of genetics for understanding and predicting antidepressant response.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče

Profili:

Avatar Url Neven Henigsberg (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Pain, Oliver; Hodgson, Karen; Trubetskoy, Vassily; Ripke, Stephan; Marshe, Victoria S.; Adams, Mark J.; Byrne, Enda M.; Campos, Adrian I.; Carrillo-Roa, Tania; Cattaneo, Annamaria et al.
Identifying the Common Genetic Basis of Antidepressant Response // Biological Psychiatry Global Open Science, 2 (2022), 2; 115-126 doi:10.1016/j.bpsgos.2021.07.008 (međunarodna recenzija, članak, znanstveni)
Pain, O., Hodgson, K., Trubetskoy, V., Ripke, S., Marshe, V., Adams, M., Byrne, E., Campos, A., Carrillo-Roa, T. & Cattaneo, A. (2022) Identifying the Common Genetic Basis of Antidepressant Response. Biological Psychiatry Global Open Science, 2 (2), 115-126 doi:10.1016/j.bpsgos.2021.07.008.
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@article{article, author = {Pain, Oliver and Hodgson, Karen and Trubetskoy, Vassily and Ripke, Stephan and Marshe, Victoria S. and Adams, Mark J. and Byrne, Enda M. and Campos, Adrian I. and Carrillo-Roa, Tania and Cattaneo, Annamaria and Als, Thomas D. and Souery, Daniel and Dernovsek, Mojca Z. and Fabbri, Chiara and Hayward, Caroline and Henigsberg, Neven and Hauser, Joanna and Kennedy, James L. and Lenze, Eric J. and Lewis, Glyn and M\"{u}ller, Daniel J. and Martin, Nicholas G. and Mulsant, Benoit H. and Mors, Ole and Perroud, Nader and Porteous, David J. and Renter\'{\i}a, Miguel E. and Reynolds, Charles F. and Rietschel, Marcella and Uher, Rudolf and Wigmore, Eleanor M. and Maier, Wolfgang and Wray, Naomi R. and Aitchison, Katherine J. and Arolt, Volker and Baune, Bernhard T. and Biernacka, Joanna M. and Bondolfi, Guido and Domschke, Katharina and Kato, Masaki and Li, Qingqin S. and Liu, Yu-Li and Serretti, Alessandro and Tsai, Shih-Jen and Turecki, Gustavo and Weinshilboum, Richard and McIntosh, Andrew M. and Lewis, Cathryn M. and Kasper, Siegfried and Zohar, Joseph and Souery, Daniel and Montgomery, Stuart and Albani, Diego and Forloni, Gianluigi and Ferentinos, Panagiotis and Rujescu, Dan and Mendlewicz, Julien and Wray, Naomi R. and Ripke, Stephan and Mattheisen, Manuel and Trzaskowski, Maciej and Byrne, Enda M. and Abdellaoui, Abdel and Adams, Mark J. and Agerbo, Esben and Air, Tracy M. and Andlauer, Till F.M. and Bacanu, Silviu- Alin and B\aekvad-Hansen, Marie and Beekman, Aartjan T.F. and Bigdeli, Tim B. and Binder, Elisabeth B. and Bryois, Julien and Buttensch\on, Henriette N. and Bybjerg-Grauholm, Jonas and Cai, Na and Castelao, Enrique and Christensen, Jane Hvarregaard and Clarke, Toni-Kim and Coleman, Jonathan R.I. and Colodro-Conde, Luc\'{\i}a and Couvy-Duchesne, Baptiste and Craddock, Nick and Crawford, Gregory E. and Davies, Gail and Deary, Ian J. and Degenhardt, Franziska and Derks, Eske M. and Direk, Nese and Dolan, Conor V. and Dunn, Erin C. and Eley, Thalia C. and Escott-Price, Valentina and Hassan Kiadeh, Farnush Farhadi and Finucane, Hilary K. and Foo, Jerome C. and Forstner, Andreas J. and Frank, Josef and Gaspar, H\'{e}l\'{e}na A. and Gill, Michael and Goes, Fernando S. and Gordon, Scott D. and Grove, Jakob and Hall, Lynsey S. and Hansen, Christine S\oholm and Hansen, Thomas F. and Herms, Stefan and Hickie, Ian B. and Hoffmann, Per and Homuth, Georg and Horn, Carsten and Hottenga, Jouke-Jan and Hougaard, David M. and Howard, David M. and Ising, Marcus and Jansen, Rick and Jones, Ian and Jones, Lisa A. and Jorgenson, Eric and Knowles, James A. and Kohane, Isaac S. and Kraft, Julia and Kretzschmar, Warren W. and Kutalik, Zolt\'{a}n and Li, Yihan and Lind, Penelope A. and MacIntyre, Donald J. and MacKinnon, Dean F. and Maier, Robert M. and Maier, Wolfgang and Marchini, Jonathan and Mbarek, Hamdi and McGrath, Patrick and McGuffin, Peter and Medland, Sarah E. and Mehta, Divya and Middeldorp, Christel M. and Mihailov, Evelin and Milaneschi, Yuri and Milani, Lili and Mondimore, Francis M. and Montgomery, Grant W. and Mostafavi, Sara and Mullins, Niamh and Nauck, Matthias and Ng, Bernard and Nivard, Michel G. and Nyholt, Dale R. and O’Reilly, Paul F. and Oskarsson, Hogni and Owen, Michael J. and Painter, Jodie N. and Pedersen, Carsten B\ocker and Pedersen, Marianne Gi\ortz and Peterson, Roseann E. and Peyrot, Wouter J. and Pistis, Giorgio and Posthuma, Danielle and Quiroz, Jorge A. and Qvist, Per and Rice, John P. and Riley, Brien P. and Rivera, Margarita and Mirza, Saira Saeed and Schoevers, Robert and Schulte, Eva C. and Shen, Ling and Shi, Jianxin and Shyn, Stanley I. and Sigurdsson, Engilbert and Sinnamon, Grant C.B. and Smit, Johannes H. and Smith, Daniel J. and Stefansson, Hreinn and Steinberg, Stacy and Streit, Fabian and Strohmaier, Jana and Tansey, Katherine E. and Teismann, Henning and Teumer, Alexander and Thompson, Wesley and Thomson, Pippa A. and Thorgeirsson, Thorgeir E. and Traylor, Matthew and Treutlein, Jens and Trubetskoy, Vassily and Uitterlinden, Andr\'{e} G. and Umbricht, Daniel and Van der Auwera, Sandra and van Hemert, Albert M. and Viktorin, Alexander and Visscher, Peter M. and Wang, Yunpeng and Webb, Bradley T. and Weinsheimer, Shantel Marie and Wellmann, J\"{u}rgen and Willemsen, Gonneke and Witt, Stephanie H. and Wu, Yang and Xi, Hualin S. and Yang, Jian and Zhang, Futao and Arolt, Volker and Baune, Bernhard T. and Berger, Klaus and Boomsma, Dorret I. and Cichon, Sven and Dannlowski, Udo and de Geus, E.J.C. and DePaulo, J. Raymond and Domenici, Enrico and Domschke, Katharina and Esko, T\~{o}nu and Grabe, Hans J. and Hamilton, Steven P. and Hayward, Caroline and Heath, Andrew C. and Kendler, Kenneth S. and Kloiber, Stefan and Lewis, Glyn and Li, Qingqin S. and Lucae, Susanne and Madden, Pamela A.F. and Magnusson, Patrik K. and Martin, Nicholas G. and McIntosh, Andrew M. and Metspalu, Andres and Mors, Ole and Mortensen, Preben Bo and M\"{u}ller-Myhsok, Bertram and Nordentoft, Merete and N\"{o}then, Markus M. and O’Donovan, Michael C. and Paciga, Sara A. and Pedersen, Nancy L. and Penninx, Brenda W.J.H. and Perlis, Roy H. and Porteous, David J. and Potash, James B. and Preisig, Martin and Rietschel, Marcella and Schaefer, Catherine and Schulze, Thomas G. and Smoller, Jordan W. and Stefansson, Kari and Tiemeier, Henning and Uher, Rudolf and V\"{o}lzke, Henry and Weissman, Myrna M. and Werge, Thomas and Lewis, Cathryn M. and Levinson, Douglas F. and Breen, Gerome and B\orglum, Anders D. and Sullivan, Patrick F.}, year = {2022}, pages = {115-126}, DOI = {10.1016/j.bpsgos.2021.07.008}, keywords = {Antidepressant response, Depression, Genetics, GWAS, MDD, Polygenic score}, journal = {Biological Psychiatry Global Open Science}, doi = {10.1016/j.bpsgos.2021.07.008}, volume = {2}, number = {2}, issn = {2667-1743}, title = {Identifying the Common Genetic Basis of Antidepressant Response}, keyword = {Antidepressant response, Depression, Genetics, GWAS, MDD, Polygenic score} }

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