Naslov
A comparison of the electrochemical properties of some colon-specific prodrugs of mesalazine

Autori
Nigović, Biljana ; Šimunić, Branimir ; Mandić, Zoran

Izvornik
Pharmazie (0031-7144) 57 (2002), 7; 468-470

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Azosalicylic acid; cyclic voltammetry; electrochemical cleavage; mesalazine

Sažetak
The electrochemical behavior of 2-hydroxy-5-[(4-sulfophenyl)azo]benzoic acid, 2-hydroxy-5-[(3-sulfophenyl)azo]benzoic acid and 2-hydroxy-5-[(2-sulfophenyl)-azo]benzoic acid was investigated by cyclic voltammetry using glassy carbon electrode. The influence of the pH and position of the substituents on the reaction pathway has been studied. The obtained results are compared to the electrochemical properties of olsalazine. The reduction of these compounds is identified as an ECE process always leading to the cleavage of azo bond. The electron-donating hydroxyl group in para position with respect to the azo bridge weakens the N-N bond, whereas the presence of the sulfo group strengthens this bond and renders the hydrazo intermediate more stable comparing to the hydrazo derivatives with two electron-donating groups in para positions.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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