Naslov
Oncological counseling of patients and families with hereditary colorectal cancer

Autori
Žigman-Žarković, Tamara ; Kirac, Iva ; Silovski, Tajana ; Vrdoljak, Danko Velimir

Izvornik
Libri Oncologici : Croatian Journal of Oncology (2584-3826) 41 (2013), 1-3; 99-103

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
hereditary colorectal cancer ; familial adenomatous polyposis ; Lynch syndrome

Sažetak
Colorectal cancer (CRC) is the third most common malignancy in the world. Thirty percent of all CRC cases are hereditary or familial forms of the disease. Approximately 5% of them represent well defined hereditary syndromes. Colon cancer syndromes are inherited autosomal dominant diseases, with exception of MUTYH associated polyposis, which is inherited in autosomal recessive manner. Most of CRC syndromes also carry significant risk of developing cancers of extra colonic localization.The clinician who deals with hereditary CRC patients should have a wide knowledge ofpresentation, genetics and cancer risks in hereditary CRC syndromes.In Croatia we donot have the center that systematically deals with CRC genetics, pharmacogenetics and hereditary CRC syndromes. Therefore, with this article, we systematically review the characteristics CRC syndromes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA