Naslov
Glomerular filtration rate is an independent prognostic factor in patients with B-large cell lymphoma

Autori
Premužić, Vedran ; Bašić-Kinda, Sandra ; Radman, Ivo ; Dujmović, Dino ; Ilić, Ivana ; Živković, Neno ; Maleta, Lucija ; Kralik, Marko ; Dobrenić, Margareta ; Galunić-Bilić, Lea ; Rončević, Pavle ; Vodanović, Marijo ; Aurer, Igor

Izvornik
Medicine (0025-7974) 102 (2023), 20; 33675, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
B-large cell, diffuse, glomerular filtration rate, lymphoma, prognosis

Sažetak
Chronic kidney dysfunction is associated with increased mortality in multiple cancer types. Preliminary evidence suggests the same to be true for B-large cell lymphomas (B-LCL). To analyze the relationship of glomerular filtration rate (GFR) and outcome of B-LCL in detail we collected data on outcomes of 285 consecutive patients with newly diagnosed B-LCL treated at our institution with standard rituximab-containing regimens who did not have preexisting kidney disease or urinary tract obstruction at presentation. Median age was 59, range 18 to 87, 145 were male and 140 females. Forty-four had GFR < 60mL/min, 123 had 60 to 90mL/ min, and 118 > 90mL/min. Median follow-up of surviving patients was 49 months and estimated 3- year survival 76%. In univariate analysis age (P < .001), GFR (P = .014), stage (P < .001), performance status (P = .044), chemotherapy regimen (P < .01), and international prognostic index (IPI) (P < .001) were statistically significant prognostic factors. In multivariate analysis, age and GFR remained the only independent prognostic factors. Subtracting 1 from the IPI score of patients who had GFR > 90mL/min and IPI > 1 resulted in a prognostic index that divides patients into 3 prognostic groups (low risk = 0–1, intermediate risk = 2–3 and high risk = 4–5) with an acceptable patient distribution frequency (38%, 39%, and 23%, respectively) and improved statistical significance and separation in comparison to IPI (5-year survival rates of 92%, 74%, and 42%, respectively). GFR is an important independent prognostic factor for B-LCL that should be taken into account in clinical decision making and data analysis and probably be incorporated in prognostic indices.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA