Naslov
In vitro killing of multidrug/extensively drug- resistant Pseudomonas aeruginosa by fosfomycin alone or in combination with antipseudomonal antibiotics

Autori
Slade-Vitković, Mia ; Bedenić, Branka ; Bielen, Luka ; Batarilo, Ivanka ; Kibel, Sara ; Maravić- Vlahoviček, Gordana

Izvornik
Journal of chemotherapy (1120-009X) (2022); 1-12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pseudomonas aeruginosa ; antibiotic synergy ; fosfomycin ; gradient diffusion strip method ; postantibiotic effect ; time-kill method

Sažetak
Pseudomonas aeruginosa is a leading cause of nosocomial infections. Given the constant rise in resistance, adequate therapy is increasingly demanding. Fosfomycin recently became an appealing treatment option of bacterial infections due to multidrug-resistant bacteria (MDR). So far, fosfomycin synergy with other antibiotics has been assessed in studies, but only a limited number focused on MDR P. aeruginosa and on the effect of these combinations on the duration of the postantibiotic effect (PAE). We investigated synergy of fosfomycin with an array of antipseudomonal antibiotics using gradient diffusion strip cross method and time-kill method, and their effect on the duration of PAE against 51 variously resistant P. aeruginosa isolates. The highest rate of synergy was observed for combination with ceftazidime (23.4%) and gentamicin (19.1%). The PAE of antibiotic combinations was superior to that of the drugs alone. Our findings indicate that fosfomycin combination therapy may be a valuable treatment alternative.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA