Pregled bibliografske jedinice broj: 1273412
N-glycosylation of plasma proteins and its genetic regulation in type 1 diabetes mellitus
N-glycosylation of plasma proteins and its genetic regulation in type 1 diabetes mellitus // Closing Meeting of the INNOGLY COST Action
Kreta, Grčka, 2023. str. 15-15 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1273412 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
N-glycosylation of plasma proteins and its genetic
regulation in type 1 diabetes mellitus
Autori
Gornik, Olga
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
Closing Meeting of the INNOGLY COST Action
Mjesto i datum
Kreta, Grčka, 02.05.2023. - 03.05.2023
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
glycosylation, type 1 diabetes
Sažetak
Type 1 diabetes (T1D) is a chronic disease characterized by the autoimmune destruction of pancreatic beta cells. Despite all medical advances, the number of children diagnosed with this disease has been increasing worldwide. This is why we performed the first study on N-glycosylation of plasma proteins in children at the onset of T1D compared to their healthy siblings to search for potential novel biomarkers that could advance diagnosis and management of the disease. We showed that an increase of the plasma and IgG oligomannose structures and structures with bisecting GlcNAc, a decrease in monogalactosylation, and an increase in IgG disialylation were associated with the disease onset and we created a predictive model that could have valuable potential in risk assessment. Using the same population, we performed genetic association study on measured N-glycans and identified novel associations that were not previously reported for the general European population. Those included a) associations between SNPs on chromosome 22 residing in two genomic intervals close to candidate gene MGAT3 and core fucosylated digalactosylated (disialylated) IgG N-glycans with bisecting GlcNAc ; b) association between two SNPs located on chromosome 19 within the protein coding region of the complement C3 gene and the oligomannose plasma N-glycan. Since the role of complement component C3 has been previously connected to diabetes development, we developed a highthroughput method and revealed differences in C3 glycopeptide pattern between children at onset of T1D and their healthy siblings
Izvorni jezik
Engleski
