Naslov
Biomarker potential of N-glycosylation or Sweet side of biomarkers

Autori
Gornik Kljaić, Olga

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Epigenetics and Male Reproductive Health Symposium - Book of Abstracts / - , 2023

Skup
Epigenetics and Male Reproductive Health Symposium

Mjesto i datum
Zagreb, Hrvatska, 29.03.2023

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
glycosylation, diabetes

Sažetak
Although neglected for many years due to their structural complexity and the demand for highly advanced laboratory technologies, oligosaccharide structures attached to human proteins, called glycans, are now rapidly emerging as potential biomarkers of different pathological conditions. Glycans are also one of the main regulators of antibody effector function and other features of the immune system. Changes in N-glycosylation have been described in various diseases as associated with disease risk, course, and therapy outcome. For instance, glycans show great potential in diabetes differentiation as well as risk assessment of future diabetes development. At the Faculty of Pharmacy and Biochemistry we possess skills and facilities to perform high-throughput analysis of glycans from different biological samples and we are constantly assessing their biomarker potential. Currently, we are conducting studies on N-glycosylation in type 1 diabetes where we revealed changes in glycosylation in children at the onset of the disease, as well as identified responsible genes. We are also collaborating with the group of Prof. Sinčić from the School of Medicine University of Zagreb in evaluating biomarker potential of glycans in prostate cancer.

Izvorni jezik
Engleski

POVEZANOST RADA