Pregled bibliografske jedinice broj: 1273385
Preparation, characterization and release of microencapsulated bromodeoxyuridine
Preparation, characterization and release of microencapsulated bromodeoxyuridine // Life sciences, 54 (1994), 1; 27-34 doi:10.1016/0024-3205(94)00574-5 (međunarodna recenzija, članak, znanstveni)
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Naslov
Preparation, characterization and release of microencapsulated
bromodeoxyuridine
(Preparation, characterization and release of microencapsulated bromodeoxyuridine)
Autori
Maysinger, Dušica ; Filipović-Grčić, Jelena ; Alebić-Kolbah, Tanja
Izvornik
Life sciences (0024-3205) 54
(1994), 1;
27-34
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
microspheres ; bromodeoxyuridine ; release ; immunocytochemistry ; brain lesions
Sažetak
Biodegradable and biocompatible microspheres with bromodeoxyuridine (BrUrd) have been prepared, characterized and tested in vitro and in vivo. Scanning electron microscopy and image analysis revealed regular spherical shapes and an average size ± SD of 2.47 ± 0.59 μm. Total content of BrUrd as determined by HPLC was within the range of 0.2 − 1.5%. Kinetic analyses of two different preparations showed similar release half-times (approx. 12 hrs), kinetic constants −0.0556, −0.0564, and −0.0557, −0.0597 [h−1], and correlation coefficients of 0.998, and 0.999 when fitted to the first order or biphasic first order kinetics, respectively. Preliminary data from immunocytochemical studies revealed efficient incorporation of BrUrd delivered from these microcapsules into nuclei of proliferating cells surrounding brain lesions in rats.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Scopus
- MEDLINE
