Naslov
Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications

Autori
Knežević, Danijel ; Ćurko-Cofek, Božena ; Batinac, Tanja ; Laškarin, Gordana ; Rakić, Marijana ; Šoštarič, Maja ; Zdravković, Marko ; Šustić, Alan ; Sotošek, Vlatka ; Batičić, Lara

Izvornik
Journal of Cardiovascular Development and Disease (2308-3425) 10 (2023), 5; 213, 23

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
anesthesia ; cardiac surgery ; endothelium ; endothelial dysfunction ; endothelial glycocalyx ; intensive care

Sažetak
Cardiac surgery is one of the highest-risk procedures, usually involving cardiopulmonary bypass and commonly inducing endothelial injury that contributes to the development of perioperative and postoperative organ dysfunction. Substantial scientific efforts are being made to unravel the complex interaction of biomolecules involved in endothelial dysfunction to find new therapeutic targets and biomarkers and to develop therapeutic strategies to protect and restore the endothelium. This review highlights the current state-of-the-art knowledge on the structure and function of the endothelial glycocalyx and mechanisms of endothelial glycocalyx shedding in cardiac surgery. Particular emphasis is placed on potential strategies to protect and restore the endothelial glycocalyx in cardiac surgery. In addition, we have summarized and elaborated the latest evidence on conventional and potential biomarkers of endothelial dysfunction to provide a comprehensive synthesis of crucial mechanisms of endothelial dysfunction in patients undergoing cardiac surgery, and to highlight their clinical implications.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne tehničke znanosti, Kliničke medicinske znanosti

POVEZANOST RADA