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Pregled bibliografske jedinice broj: 1272330

Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: Focus on antioxidant, anti- inflammatory, and antimicrobial activities in vitro

Ferrante, Claudio; Recinella, Lucia; Ronci, Maurizio; Orlando, Giustino; Di Simone, Simonetta; Brunetti, Luigi; Chiavaroli, Annalisa; Leone, Sheila; Politi, Matteo; Tirillini, Bruno et al.
Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: Focus on antioxidant, anti- inflammatory, and antimicrobial activities in vitro // PTR. Phytotherapy research, 33 (2019), 9; 2387-2400 doi:10.1002/ptr.6429 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1272330 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: Focus on antioxidant, anti- inflammatory, and antimicrobial activities in vitro

Autori
Ferrante, Claudio ; Recinella, Lucia ; Ronci, Maurizio ; Orlando, Giustino ; Di Simone, Simonetta ; Brunetti, Luigi ; Chiavaroli, Annalisa ; Leone, Sheila ; Politi, Matteo ; Tirillini, Bruno ; Angelini, Paola ; Covino, Stefano ; Venanzoni, Roberto ; Vladimir-Knežević, Sanda ; Menghini, Luigi

Izvornik
PTR. Phytotherapy research (0951-418X) 33 (2019), 9; 2387-2400

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antimicrobial activity ; inflammation ; oxidative stress ; Phlomis ; ulcerative colitis

Sažetak
Phlomis fruticosa L. and P. herba-venti are species belonging to the Lamiaceae family, which have been traditionally used to prepare tonic and digestive drinks. Multiple studies also demonstrated the inhibitory effects of P. fruticosa extracts and essential oil against oxidative/proinflammatory pathways and bacterial strains deeply involved in ulcerative colitis. Considering these findings, the present study evaluated the effects of alcoholic P. fruticosa and P. herba-venti leaf extracts in isolated rat colon challenged with Escherichia coli lipopolysaccharide (LPS), an ex vivo experimental paradigm of ulcerative colitis. In this context, we assayed colon levels of pro-oxidant and proinflammatory biomarkers, including nitrites, malondialdehyde (MDA), lactate dehydrogenase (LDH), and serotonin (5-HT). Additionally, the extracts have been tested in order to evaluate possible inhibitory effects on specific bacterial and fungal strains involved in ulcerative colitis. Alcoholic P. fruticosa and P. herba-venti extracts were able to blunt LPS-induced nitrite, MDA, 5-HT, and LDH levels in isolated rat colon. The same extracts also inhibited the growth of Pseudomonas aeruginosa, E. coli, Staphylococcus aureus, Candida albicans and Candida tropicalis. In conclusion, our findings show a potential role exerted by alcoholic P. fruticosa and P. herba- venti in managing the clinical symptoms related to ulcerative colitis.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Sanda Vladimir-Knežević (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi doi.org onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Ferrante, Claudio; Recinella, Lucia; Ronci, Maurizio; Orlando, Giustino; Di Simone, Simonetta; Brunetti, Luigi; Chiavaroli, Annalisa; Leone, Sheila; Politi, Matteo; Tirillini, Bruno et al.
Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: Focus on antioxidant, anti- inflammatory, and antimicrobial activities in vitro // PTR. Phytotherapy research, 33 (2019), 9; 2387-2400 doi:10.1002/ptr.6429 (međunarodna recenzija, članak, znanstveni)
Ferrante, C., Recinella, L., Ronci, M., Orlando, G., Di Simone, S., Brunetti, L., Chiavaroli, A., Leone, S., Politi, M. & Tirillini, B. (2019) Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: Focus on antioxidant, anti- inflammatory, and antimicrobial activities in vitro. PTR. Phytotherapy research, 33 (9), 2387-2400 doi:10.1002/ptr.6429.
@article{article, author = {Ferrante, Claudio and Recinella, Lucia and Ronci, Maurizio and Orlando, Giustino and Di Simone, Simonetta and Brunetti, Luigi and Chiavaroli, Annalisa and Leone, Sheila and Politi, Matteo and Tirillini, Bruno and Angelini, Paola and Covino, Stefano and Venanzoni, Roberto and Vladimir-Kne\v{z}evi\'{c}, Sanda and Menghini, Luigi}, year = {2019}, pages = {2387-2400}, DOI = {10.1002/ptr.6429}, keywords = {antimicrobial activity, inflammation, oxidative stress, Phlomis, ulcerative colitis}, journal = {PTR. Phytotherapy research}, doi = {10.1002/ptr.6429}, volume = {33}, number = {9}, issn = {0951-418X}, title = {Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: Focus on antioxidant, anti- inflammatory, and antimicrobial activities in vitro}, keyword = {antimicrobial activity, inflammation, oxidative stress, Phlomis, ulcerative colitis} }
@article{article, author = {Ferrante, Claudio and Recinella, Lucia and Ronci, Maurizio and Orlando, Giustino and Di Simone, Simonetta and Brunetti, Luigi and Chiavaroli, Annalisa and Leone, Sheila and Politi, Matteo and Tirillini, Bruno and Angelini, Paola and Covino, Stefano and Venanzoni, Roberto and Vladimir-Kne\v{z}evi\'{c}, Sanda and Menghini, Luigi}, year = {2019}, pages = {2387-2400}, DOI = {10.1002/ptr.6429}, keywords = {antimicrobial activity, inflammation, oxidative stress, Phlomis, ulcerative colitis}, journal = {PTR. Phytotherapy research}, doi = {10.1002/ptr.6429}, volume = {33}, number = {9}, issn = {0951-418X}, title = {Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: Focus on antioxidant, anti- inflammatory, and antimicrobial activities in vitro}, keyword = {antimicrobial activity, inflammation, oxidative stress, Phlomis, ulcerative colitis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • Abstracts in Anthropology
  • AGRICOLA

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