Naslov
Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

Autori
Menghini, Luigi ; Recinella, Lucia ; Leone, Sheila ; Chiavaroli, Annalisa ; Cicala, Carla ; Brunetti, Luigi ; Vladimir-Knežević, Sanda ; Orlando, Giustino ; Ferrante, Claudio

Izvornik
PTR. Phytotherapy research (0951-418X) 33 (2019); 2152-2162

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
arthritis ; atherosclerosis ; inflammatory bowel disease ; neurodegenerative diseases ; osteoporosis ; type 1 diabetes

Sažetak
Devil's claw (Harpagophytum procumbens) is an herbaceous plant, which can be found in the arid steppes of South Africa, particularly in the Kalahari Desert. As traditional medicine, devil's claw has been long used in the forms of infusions, decoctions, tinctures, powders, and extracts. The main compounds of devil's claw are iridoid glycosides, such as harpagoside, harpagide, and procumbide, which are present in the plant tubers. Additionally, chemical constituents such as sugars (mainly the tetrasaccharide stachyose), triterpenoids (oleanolic and ursolic acid), phytosterols (primarily β-sitosterol), aromatic acids (caffeic, cinnamic, and chlorogenic acids), and flavonoids (luteolin and kaempferol) can be found in the plant. In order to investigate the applicative potential of devil's claw as therapeutic agent, we performed a review by focusing on its potential role in managing inflammation- and oxidative stress-related diseases, including arthritis, osteoporosis, inflammatory bowel disease, low-back pain, diabetes, and neurodegeneration.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA