Naslov
The Role of Microbiota in Health and Diseases

Autori
Verbanac, Donatella

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, kratko priopćenje, znanstveni

Izvornik
Croatian Society for Pelviperineology 1st Annual Congress with International Participation ; November 23th-24th, 2018 Hotel Terme Jezerčica, Donja Stubica, Croatia SUMMARY BOOK / Fureš, Rajko ; Hodžić, Damir - Zagreb : Croatian Society for Pelviperineology, 2018, 30-31

Skup
Croatian Society for Pelviperineology 1st Annual Congress with International Participation ; November 23th-24th, 2018 Hotel Terme Jezerčica, Donja Stubica, Croatia

Mjesto i datum
Donja Stubica, Hrvatska, 23.11.2018. - 24.11.2018

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
gut microbiota ; vaginal microbiota ; dysbiosis ; probiotics ; prebiotics ; synbiotics ; inflammation

Sažetak
The Role of Microbiota in Health and Diseases •AUTHORS Associated Professor Donatella Verbanac, PhD •AFFILIATION University of Zagreb Faculty of Pharmacy and Biochemistry, Department for Medical Biochemistry and Hematology, Zagreb 10 000 ; A. Kovačića 1 •INTRODUCTION AND AIM The gut microbiota is an organ within our body composed of ten trillion microorganisms with a mass of almost 2.5 kilos. Microbiota is mainly acquired during birth and early childhood and exhibits protective, functional, and metabolic roles when in perfect balance or eubiosis. By providing additional metabolic functions and regulation of gene expression, microbiota improves the ability to extract and store energy from the diet. It contributes to maintaining a healthy and balanced body weight. An imbalance in the gut microbiota (dysbiosis) leads to conditions associated with chronic, persistent inflammation. The dysbiosis in the gut also triggers the dysbiosis in the urogenital system. This phenomenon is still a matter of investigation and represents a new approach to treating persistent infections/ inflammation in the vaginal tract. •MATERIALS AND METHODS Data obtained in experimental models and human subjects favor modulating/changing the gut microbiota may contribute to the control of the development of metabolic and associated diseases. •RESULTS Supplementation with probiotics, prebiotics, and synbiotics has shown promising results against various intestinal and urogenital pathogens. This is due to the unique ability of probiotic bacteria to compete with pathogenic microbiota for adhesion sites and the availability of the nutrients, such as glycogen. Probiotics are also able to neutralize pathogens with the production of hydrogen peroxide and antibacterial peptides. Finally, they modulate and regulate our immune response by activating specific genes in and outside of the intestinal tract. •CONCLUSIONS The possibilities of modulating the vaginal microbiota and restoring its natural eubiosis via different strategies are part of new approaches developed to protect women's health in general. •REFERENCES 1. Matijašić et al, Int J Mol Sci. 2016 Apr19 ; 7(4). 2. García-Velasco et al, Rep Biomed on-line, 2017 ; 103. 3. Panek et al, Sci Rep. 2018 Mar 23 ; 8(1):5143.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA