Naslov
Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000–2014 (CONCORD-3)

Autori
Girardi, Fabio ; Di Carlo, Veronica ; Stiller, Charles ; Gatta, Gemma ; Woods, Ryan R ; Visser, Otto ; Lacour, Brigitte ; Tucker, Thomas C ; Coleman, Michel P ; Allemani, Claudia ; Bouzbid, S ; Hamdi-Chérif, M ; Kara, L ; Meguenni, K ; Regagba, D ; Bayo, S ; ... ; Sekerija, Mario ; ... ; Lewis, C ; CONCORD Working Group

Kolaboracija
CONCORD Working Group

Izvornik
Neuro-Oncology (1522-8517) 25 (2022), 3; 593-606

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
brain tumor ; cancer registries ; childhood cancer ; international comparisons ; survival

Sažetak
Introduction: Tumors of the central nervous system are among the leading causes of cancer-related death in children. Population-based cancer survival reflects the overall effectiveness of a health care system in managing cancer. Inequity in access to care world-wide may result in survival disparities. Methods: We considered children (0-14 years) diagnosed with a brain tumor during 2000-2014, regardless of tumor behavior. Data underwent a rigorous, three-phase quality control as part of CONCORD-3. We implemented a revised version of the International Classification of Childhood Cancer (third edition) to control for under-registration of non-malignant astrocytic tumors. We estimated net survival using the unbiased nonparametric Pohar Perme estimator. Results: The study included 67, 776 children. We estimated survival for 12 histology groups, each based on relevant ICD-O-3 codes. Age-standardized 5-year net survival for low-grade astrocytoma ranged between 84% and 100% world-wide during 2000- 2014. In most countries, 5-year survival was 90% or more during 2000-2004, 2005-2009, and 2010-2014. Global variation in survival for medulloblastoma was much wider, with age-standardized 5-year net survival between 47% and 86% for children diagnosed during 2010-2014. Conclusions: To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors in children, by histology. We devised an enhanced version of ICCC-3 to account for differences in cancer registration practices world- wide. Our findings may have public health implications, because low-grade glioma is 1 of the 6 index childhood cancers included by WHO in the Global Initiative for Childhood Cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA