Naslov
A rare presentation of Langerhans cell sarcoma in the parotid gland

Autori
Stela Marković, Josipa Živko, Vesna Bišofa

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2022 / - Zagreb : Liječ Vjesn God. | Vol. 144 [2022] Broj | Num. Supl. 2 Str. | Pag. 1–112 Zagreb, Hrvatska |Croatia, 2022, 54-54

Skup
17th Croatian Student Summit

Mjesto i datum
Zagreb, Hrvatska, 27.04.2022. - 30.04.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Langerhans cell sarcoma, radiotherapy, rare tumor, salivary glands

Sažetak
INTRODUCTION/OBJECTIVES: Langerhans cell sarcoma (LCS) is a very rare, high-grade malignancy of the Langerhans cells and may vary from isolated lesion to multifocal disease. Parotid gland involvement is an exceptionally rare clinical presentation of LCS even in patients with multifocal disease. CASE PRESENTATION: We report a case of LCS in the left parotid gland that occurred in a 63-year-old male. The patient presented with a palpable mass on the left side of the face. Ultrasonography showed three hypoechoic nodules in the left parotid gland. The patient underwent parotidectomy and selective neck dissection levels II-III. Immunohistochemical studies of the tumor tissue showed marked positivity to S100 and CD68, and focally positive CD1A staining. The presence of Birbeck granules on electron microscopy couldn’t be reliably established. With 20 mitoses per 10 HPFs, tumor tissue exhibited high proliferative activity. Tumor was confined to the parotid gland with no involvement of adjacent lymph nodes. On the initial assessment, there were no signs of systemic dissemination. Four months post parotidectomy, PET-CT revealed focally increased metabolism in the soft tissue nodule located along the posterior edge of the gonial angle on the left side protruding medially, which raised suspicion of disease recurrence. Ultrasonically guided FNA did not show the presence of malignant cells. Surgery was followed by adjuvant radiotherapy 66 Gy in 33 fractions. There has been no evidence of recurrence or disease progression over the past 14 months since diagnosis. CONCLUSION: LCS should be kept in mind in the differential diagnosis in patients with parotid enlargement.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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