Naslov
Genetic and epigenetic markers as indicators of aggressiveness of differentiated thyroid cancer

Autori
Šamija, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Epigenetics and Male Reproductive Health Symposium book of Abstracts / - , 2023, 21-21

Skup
Epigenetics and Male Reproductive Health Symposium

Mjesto i datum
Zagreb, Hrvatska, 29.03.2023

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
thyroid cancer, prognostic markers, BRAF mutations, TERT promotor mutations, epigenetic markers

Sažetak
In this presentation research project ‘Genetic and epigenetic markers as indicators of aggressiveness of differentiated thyroid cancer’ founded by Croatian Science Foundation and collaboration with Scientific Group for Research on Epigenetic Biomarkers (epiMark) will be presented. Thyroid carcinoma, despite its predominantly indolent course, represents a significant burden on the health system with its high incidence. Recent publications emphasize the need for advancement in molecular diagnostics for the purpose of detecting a new markers of prognostic significance for the aggressiveness of the disease that is characterized by recurrence or persistence of the disease, the development of regional and distant metastases or the resistance on today's accepted radioiodine therapy. This project seeks to explore the benefit of BRAF and TERT mutation analysis and the epigenetic changes in the TERT promoter in patients in relation to the aggressiveness of differentiated thyroid carcinoma. The field of epigenetic modifications in the disease pathophysiology is poorly investigated and the analysis of epigenetic changes is one of the important advantages of this project. By confirming the usefulness of these markers, routine analysis of said markers in patients with differentiated thyroid carcinoma would be introduced in clinical practice in order to provide early selection of patients requiring further treatment, diagnosis and monitoring and possibly for selection of patients suitable for therapy with B-RAF inhibitors.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA