Naslov
Healthcare-Associated Bloodstream Infections Due to Multidrug-Resistant Acinetobacter baumannii in COVID-19 Intensive Care Unit: A Single-Center Retrospective Study

Autori
Dobrović, Karolina ; Škrobo, Tea ; Selec, Katarina ; Jelić, Marko ; Čivljak, Rok ; Peršec, Jasminka ; Sakan, Sanja ; Bušić, Nikolina ; Mihelčić, Antonija ; Hleb, Sonja ; Andrašević, Arjana Tambić

Izvornik
Microorganisms (2076-2607) 11 (2023), 3; 774-13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acinetobacter baumannii ; blaOXA-23 ; bloodstream infection ; carbapenemase genes ; carbapenem re-sistance ; COVID-19 ; healthcare-associated infections ; intensive care units ; multidrug-resistant

Sažetak
Abstract: Healthcare-associated infections have been an emerging cause of morbidity and mortality in COVID-19 intensive care units (ICUs) worldwide, especially those caused by multi-drug resistant (MDR) pathogens. The objectives of this study were to assess the incidence of bloodstream infections (BSIs) among critically ill COVID-19 patients and to analyze characteristics of healthcare- associated BSIs due to MDR Acinetobacter baumannii in a COVID-19 ICUs. A single center retrospective study was conducted at a tertiary care hospital during a 5-months period. Detection of carbapenemase genes was performed by PCR while genetic relatedness by pulsed-field gel electrophoresis (PFGE) and multilocus-sequence typing (MLST). A total of 193 episodes of BSIs were registered in 176 COVID-19 ICU patients, with incidence of 25/1000 patient-days at risk. A. baumannii was the most common etiological agent (40.3%) with resistance to carbapenems of 100%. The blaOXA-23 gene was detected in ST2 isolates while blaOXA-24 gene was ST636 specific. PFGE analysis revealed homogeneous genetic background of the isolates. Clonal spread of OXA-23 positive A. baumannii is responsible for high prevalence of MDR A. baumannii BSIs in our COVID-19 ICUs. Further surveillance of resistance trends and mechanisms are needed along with behavior change towards better implementation of infection control and rational use of antibiotics.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA