Naslov
Carcinoma of the parathyroid gland: a case report

Autori
Kostić, Matea ; Kostić, Andrea ; Baretić, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Liječnički vijesnik / Anić, Branimir - Zagreb, 2023, 55-55

Skup
18th Croatian Student Summit - CROSS

Mjesto i datum
Zagreb, Hrvatska, 25.04.2023. - 28.04.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
carcinoma ; parathyroid gland ; hypercalcaemia

Sažetak
Carcinoma of the parathyroid gland is a rare malignant disease, causing 0.005% of all malignancies. Although the aetiology of parathyroid cancer remains unknown, possible contributing factors include neck radiation or chronic secondary hyperparathyroidism due to kidney failure and vitamin D deficiencies. It occurs in multiple syndromes such as hyperparathyroidism-jaw tumour syndrome, multiple endocrine neoplasia types 1 and 2A, and familial isolated hyperparathyroidism. The patient is a 63-year-old woman who has had hypercalcemia for three years, followed by nephrolithiasis, hypertension, and osteoporosis. In medical history, she underwent radiotherapy and chemotherapy for sarcoma of the femur. Laboratory results showed that the level of calcium was 3.85 mmol/l, ionized calcium was 1.98 mmol/L, phosphorus was 0.56 mmol/L, and parathyroid hormone levels were greater than 150 pmol/L. Her bone x-ray showed typical features of osteitis fibrosa cystica. An ultrasound of the neck showed a 4-centimetre-large lower parathyroid gland. The patient underwent a thyroid lobectomy and parathyroidectomy on the left side. Pathohistological results showed capsular invasion, extension to the surrounding connective tissue, and angioinvasion. After the surgery, the patient suffered severe hypocalcemia and was treated with oral and intravenous calcium, calcitriol, and hydrochlorothiazide. Vitamin D and calcium supplements were used as long-term treatments. Follow-up was made throughout the year after surgery, and ultrasound and PET CT showed no morphogenic or metabolic signs of local recurrence of the disease. Parathyroid gland carcinoma is a rare malignant disease. In this case, the patient had a history of long-standing hypercalcemia with metabolic and bone consequences of nephrolithiasis, osteitis fibrosis cystica, and hypertension. Carcinoma of the parathyroid gland should be considered in patients with such metabolic traits, marked hypercalcemia and hyperparathyroidism. The treatment is surgical.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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