Naslov
THE EFFECT OF BPC-157 ON THE SYSTEMIC EFFECTS OF INDUCED OPEN ANGLE GLAUCOMA IN RAT MODEL

Autori
Sablić, Marko ; Vuković, Vlasta ; Kokot, Antonio ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharmaca 2022 ; 52 Suppl 2 / Mršić-Pelčić, Jasenka ; Vitezić, Dinko ; Janković, Tamara - Zagreb, 2022, 211-211

Skup
10th Croatian Congress of Pharmacology and the 1st Croatian Congress of Clinical Pharmacology with International Participation

Mjesto i datum
Opatija, Hrvatska, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BPC 157 ; Rat ; Glaucoma ;

Sažetak
Introduction: Using rat open-angle glaucoma model (cauterization of the three of the four episcleral veins), we demonstrated a particular beneficial effect of BPC 157 therapy on the glaucomatous eye injury (Biomedicines. 2021 ; 10(1):89). Per-oral, intraperitoneal and local eye therapy with stable gastric pentadecapeptide BPC 157 regimens immediately normalized intraocular pressure, and at the end, preserved ganglion cells with normal fundus, retinal and choroidal blood vessel and optic nerve presentation. With the evidence that the upgraded minor vessel may take over the function of the failed major vessel, and reorganize blood flow, we combined this anti-glaucomatous effect in the rat eye with the recovery of the other vascular and multiorgan failures-induced various occlusion/occlusion like syndromes induced with major occlusion and other alike noxious procedures. Now, we focused the beneficial effects of BPC 157 on rat glaucoma as vascular failure and multiorgan failure-induced occlusion/occlusion like syndrome, and therapy as whole. Materials and methods/Results: In the glaucomatous rats (Biomedicines. 2021 ; 10(1):89.), using assessment previously described (Biomedicines. 2022 ; 10(7):1462), BPC 157 therapy (intragastrically, two drops in each eye, subcutaneously) counteracted the noxious course of the occlusion/occlusion like syndrome as whole given at 15 min, or latter (1, 24, 48h after cauterization). In addition to the rapid normalization of intraocular pressure, counteracted were specifically the intracranial (superior sagittal sinus) hypertension, portal hypertension, aortal hypotension, thrombosis and the organs lesions (i.e. post-injury brain swelling was instantly reversed) as described in the therapy of the other occlusion/occlusion like syndromes. Conclusion. These findings favor further BPC 157 anti-glaucomatous therapy.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti

POVEZANOST RADA